Abstract
Platelet adhesiveness to glass beads was measured in citrated blood at intervals up to two hours after the addition of adenosine diphosphate (A.D.P.). Adhesiveness increased for 15 minutes, fell towards the original level, and then steadily increased. The initial changes were associated with the formation and subsequent dispersal of platelet clumps. The sequence of events resembled the reported platelet aggregation, the disaggregation and secondary aggregation effect of A.D.P. and emphasizes the importance of a standard technique in the measurement of A.D.P.-induced platelet adhesiveness.
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- BORN G. V. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962 Jun 9;194:927–929. doi: 10.1038/194927b0. [DOI] [PubMed] [Google Scholar]
- Baar H. S. The Enumeration of Blood Platelets. J Clin Pathol. 1948 May;1(3):175–176. [PMC free article] [PubMed] [Google Scholar]
- EASTHAM R. D. RAPID ADHESIVE PLATELET COUNT IN WHOLE BLOOD. J Clin Pathol. 1964 Jan;17:45–46. doi: 10.1136/jcp.17.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GAARDER A., JONSEN J., LALAND S., HELLEM A., OWREN P. A. Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets. Nature. 1961 Nov 11;192:531–532. doi: 10.1038/192531a0. [DOI] [PubMed] [Google Scholar]
- HELLEM A. J., ODEGAARD A. E. INVESTIGATIONS ON ADENOSINE DIPHOSPHATE (ADP) INDUCED PLATELET ADHESIVENESS IN VITRO. I. THE ADP-PLATELET REACTION IN VARIOUS EXPERIMENTAL CONDITIONS. Thromb Diath Haemorrh. 1963 Nov 1;10:61–70. [PubMed] [Google Scholar]
- Macmillan D. C. Secondary clumping effect in human citrated platelet-rich plasma produced by adenosine diphosphate and adrenaline. Nature. 1966 Jul 9;211(5045):140–144. doi: 10.1038/211140a0. [DOI] [PubMed] [Google Scholar]
- O'brien J. R. Platelet aggregation: Part I Some effects of the adenosine phosphates, thrombin, and cocaine upon platelet adhesiveness. J Clin Pathol. 1962 Sep;15(5):446–452. doi: 10.1136/jcp.15.5.446. [DOI] [PMC free article] [PubMed] [Google Scholar]
- OWREN P. A., HELLEM A. J., ODEGAARD A. LINOLENIC ACID FOR THE PREVENTION OF THROMBOSIS AND MYOCARDIAL INFARCTION. Lancet. 1964 Nov 7;2(7367):975–978. doi: 10.1016/s0140-6736(64)90928-6. [DOI] [PubMed] [Google Scholar]