Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1967 Nov;20(6):870–874. doi: 10.1136/jcp.20.6.870

Resistance to cloxacillin among hospital staphylococci

G C Turner 1,1, P E Cox 1
PMCID: PMC473629  PMID: 5188891

Abstract

Cloxacillin-resistant strains of Staphylococcus aureus were detected by their ability to grow on agar containing 1·6 μg./ml. of cloxacillin, a more reliable method than the disc-diffusion test.

At Sefton General Hospital, Liverpool, between 1963 and 1965, there was an increase in the number of infections among in-patients that were caused by staphylococci resistant to cloxacillin despite the fact that use of the antibiotic was largely confined to an isolation ward for patients with staphylococcal sepsis.

Although there is no evidence yet that staphylococci resistant to cloxacillin will become as common in hospital practice as those resistant to penicillin and tetracycline it is clear that there is a need for continued vigilance and measures to prevent spread of staphylococci from infected patients.

Full text

PDF
870

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARBER M., BURSTON J. Antibiotic-resistant staphylococcal infection; a study of antibiotic sensitivity in relation to bacteriophage types. Lancet. 1955 Sep 17;269(6890):578–583. doi: 10.1016/s0140-6736(55)92582-4. [DOI] [PubMed] [Google Scholar]
  2. Burgess H. A., Evans R. J. Failure of cephaloridine in a case of staphylococcal endocarditis. Br Med J. 1966 Nov 19;2(5524):1244–1244. doi: 10.1136/bmj.2.5524.1244. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. COLLEY E. W., MCNICOL M. W., BRACKEN P. M. METHICILLIN-RESISTANT STAPHYLOCOCCI IN A GENERAL HOSPITAL. Lancet. 1965 Mar 13;1(7385):595–597. doi: 10.1016/s0140-6736(65)91165-7. [DOI] [PubMed] [Google Scholar]
  4. HILSON G. R. In-vitro studies of a new antibiotic (fucidin). Lancet. 1962 May 5;1(7236):932–933. doi: 10.1016/s0140-6736(62)91970-0. [DOI] [PubMed] [Google Scholar]
  5. Jevons M. P., John M., Parker M. T. Cultural characters of a newly recognized group of hospital staphylococci. J Clin Pathol. 1966 Jul;19(4):305–312. doi: 10.1136/jcp.19.4.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KNOX R., SMITH J. T. Stability of methiciilin and cloxacillin to staphylococcal penicillinase. Br Med J. 1963 Jul 27;2(5351):205–207. doi: 10.1136/bmj.2.5351.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. RICHMOND M. H., PARKER M. T., JEVONS M. P., JOHN M. HIGH PENICILLINASE PRODUCTION CORRELATED WITH MULTIPLE ANTIBIOTIC RESISTANCE IN STAPHYLOCOCCUS AUREUS. Lancet. 1964 Feb 8;1(7328):293–296. doi: 10.1016/s0140-6736(64)92407-9. [DOI] [PubMed] [Google Scholar]
  8. Ridley M., Phillips I. Relative instability of cephaloridine to staphylococcal penicillinase. Nature. 1965 Dec 11;208(5015):1076–1078. doi: 10.1038/2081076a0. [DOI] [PubMed] [Google Scholar]
  9. STEWART G. T., HOLT R. J. Evolutio of natural resistance to the newer penicillins. Br Med J. 1963 Feb 2;1(5326):308–311. doi: 10.1136/bmj.1.5326.308. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. SUTHERLAND R., ROLINSON G. N. CHARACTERISTICS OF METHICILLIN-RESISTANT STAPHYLOCOCCI. J Bacteriol. 1964 Apr;87:887–899. doi: 10.1128/jb.87.4.887-899.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. TURNER G. C., WATSON D. C., ABBOTT J. D. AN ISOLATION WARD FOR PATIENTS WITH STAPHYLOCOCCAL SEPSIS. Lancet. 1965 Aug 28;2(7409):426–429. doi: 10.1016/s0140-6736(65)90771-3. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES