Abstract
Serum α2-macroglobulin levels were measured in normal subjects and in patients with various diseases by an immunochemical method.
The values for normal men were 284 mg./100 ml. (±89·6 mg./100 ml.) and for normal women 350 mg./100 ml. (±94·5 mg./100 ml.).
Men with rheumatoid arthritis had normal levels, but the levels in women were depressed. There was no relationship to the concentrations of the acute phase reactive proteins, haptoglobin, and C-reactive protein.
In chronic liver disease, the levels in men were significantly higher than normal and were slightly higher than normal in women.
A small group of patients with nephrotic syndrome had very high levels.
No significant variations from the normal were found in sera from a group of patients with miscellaneous diseases.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- CROCKSON R. A. A gel diffusion precipitin method for the estimation of C-reactive protein. J Clin Pathol. 1963 May;16:287–289. doi: 10.1136/jcp.16.3.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Crockson R. A., Payne C. J., Ratcliff A. P., Soothill J. F. Time sequence of acute phase reactive proteins following surgical trauma. Clin Chim Acta. 1966 Oct;14(4):435–441. doi: 10.1016/0009-8981(66)90030-1. [DOI] [PubMed] [Google Scholar]
- FAHEY J. L., MCLAUGHLIN C. PREPARATION OF ANTISERA SPECIFIC FOR 6.6 S GAMMA-GLOBULINS, BETA 2A-GLOBULINS, GAMMA-1.-MACROGLOBULINS, AND FOR TYPE I AND II COMMON GAMMA-GLOBULIN DETERMINANTS. J Immunol. 1963 Oct;91:484–497. [PubMed] [Google Scholar]
- HADDEN D. R., PROUT T. E. A GROWTH HORMONE BINDING PROTEIN IN NORMAL HUMAN SERUM. Nature. 1964 Jun 27;202:1342–1343. doi: 10.1038/2021342a0. [DOI] [PubMed] [Google Scholar]
- HAVERBACK B. J., DYCE B., BUNDY H. F., WIRTSCHAFTER S. K., EDMONDSON H. A. Protein binding of pancreatic proteolytic enzymes. J Clin Invest. 1962 May;41:972–980. doi: 10.1172/JCI104576. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HITZIG W. H. [On the quantitative determination of specific protein fractions. Methodical studies with special reference to immunochemical methods. I]. Int Arch Allergy Appl Immunol. 1961;19:145–167. [PubMed] [Google Scholar]
- Lanchantin G. F., Plesset M. L., Friedmann J. A., Hart D. W. Dissociation of esterolytic and clotting activities of thrombin by trypsin-binding macroglobulin. Proc Soc Exp Biol Med. 1966 Feb;121(2):444–449. doi: 10.3181/00379727-121-30800. [DOI] [PubMed] [Google Scholar]
- MEHL J. W., O'CONNELL W., DEGROOT J. MACROGLOBULIN FROM HUMAN PLASMA WHICH FORMS AN ENZYMATICALLY ACTIVE COMPOUND WITH TRYPSIN. Science. 1964 Aug 21;145(3634):821–822. doi: 10.1126/science.145.3634.821. [DOI] [PubMed] [Google Scholar]
- OWEN J. A., SMITH R., PADANYI R., MARTIN J. SERUM HAPTOGLOBIN IN DISEASE. Clin Sci. 1964 Feb;26:1–6. [PubMed] [Google Scholar]
- RATCLIFF A. P., HARDWICKE J. ESTIMATION OF SERUM HAEMOGLOBIN-BINDING CAPACITY (HAPTOGLOBIN) ON SEPHADEX G.100. J Clin Pathol. 1964 Nov;17:676–679. doi: 10.1136/jcp.17.6.676. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHULTZE H. E., SCHWICK G. Quantitative immunologische Bestimmung von Plasmaproteinen. Clin Chim Acta. 1959 Jan;4(1):15–25. doi: 10.1016/0009-8981(59)90075-0. [DOI] [PubMed] [Google Scholar]
- SCHUMACHER G., SCHLUMBERGER H. D. [On changes in the alpha 2 globulins of the serum]. Dtsch Med Wochenschr. 1963 Mar 29;88:645–651. doi: 10.1055/s-0028-1111992. [DOI] [PubMed] [Google Scholar]
- TAGNON H. J., LIEBERMAN S., SCHULMAN P., BRUNSCHWIG A. The metabolism of estrogens by the human liver studied in vitro. J Clin Invest. 1952 Apr;31(4):346–350. doi: 10.1172/JCI102614. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WALTON K. W., SCOTT P. J. ESTIMATION OF THE LOW-DENSITY (BETA) LIPOPROTEINS OF SERUM IN HEALTH AND DISEASE USING LARGE MOLECULAR WEIGHT DEXTRAN SULPHATE. J Clin Pathol. 1964 Nov;17:627–643. doi: 10.1136/jcp.17.6.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WRIGHT S. T. A quantitative serum-agar technique. Nature. 1959 May 2;183(4670):1282–1283. doi: 10.1038/1831282b0. [DOI] [PubMed] [Google Scholar]
- Zahnd G. R., Scheidegger J. J. Rôle de la macroglobuline-alpha-2-du sérum humain dans la fixation in vitro de l'insuline bovine marquée à l'iode-131. Helv Med Acta. 1963 Nov;30(4):506–511. [PubMed] [Google Scholar]