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. 1968 Jan;21(1):32–34. doi: 10.1136/jcp.21.1.32

Primary `acquired' hypogammaglobulinaemia and amyloidosis

W D Murray 1,2,3,1, I A Cook 1,2,3
PMCID: PMC473658  PMID: 5697332

Abstract

The clinical details and post-mortem findings are given of a patient who had primary `acquired' hypogammaglobulinaemia and was found at necropsy to have amyloidosis. The relationship of gamma globulin deficiency to amyloidosis is discussed, and the possible relevance of the hypogammaglobulinaemia to the formation and nature of amyloid is noted. It is suggested that a disordered immune response may be an essential prerequisite for the development of amyloidosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRADBURY S., MICKLEM H. S. AMYLOIDOSIS AND LYMPHOID APLASIA IN MOUSE RADIATION CHIMERAS. Am J Pathol. 1965 Feb;46:263–277. [PMC free article] [PubMed] [Google Scholar]
  2. CATHCART E. S., COMERFORD F. R., COHEN A. S. IMMUNOLOGIC STUDIES ON A PROTEIN EXTRACTED FROM HUMAN SECONDARY AMYLOID. N Engl J Med. 1965 Jul 15;273:143–146. doi: 10.1056/NEJM196507152730306. [DOI] [PubMed] [Google Scholar]
  3. COOK I. A., MELROSE A. G. Acquired hypogammaglobulinaemia in an adult. Scott Med J. 1958 Mar;3(3):135–139. doi: 10.1177/003693305800300306. [DOI] [PubMed] [Google Scholar]
  4. Cathcart E. S., Cohen A. S. The relation between isolated human amyloid fibrils and human gamma-globulin and its subunits. J Immunol. 1966 Feb;96(2):239–244. [PubMed] [Google Scholar]
  5. Conn H. O., Quintiliani R. Severe diarrhea controlled by gamma globulin in a patient with agammaglobulinemia, amyloidosis, and thymoma. Ann Intern Med. 1966 Sep;65(3):528–541. doi: 10.7326/0003-4819-65-3-528. [DOI] [PubMed] [Google Scholar]
  6. FORSSMAN O., HERNER B. ACQUIRED AGAMMAGLOBULINAEMIA AND MALABSORPTION. Acta Med Scand. 1964 Dec;176:779–786. [PubMed] [Google Scholar]
  7. GLEICH G. J., CONDEMI J. J., VAUGHAN J. H. DYSGAMMAGLOBULINEMIA IN THE PRESENCE OF PLASMA CELLS. N Engl J Med. 1965 Feb 18;272:331–340. doi: 10.1056/NEJM196502182720702. [DOI] [PubMed] [Google Scholar]
  8. GRAS J., LATORRE J., GAMISSANS J. M. Hypo-Agamma-Globulinämie bei einem Fall von Amyloidose. Klin Wochenschr. 1954 Oct 15;32(39-40):968–971. doi: 10.1007/BF01466991. [DOI] [PubMed] [Google Scholar]
  9. Gabrielsen A. E., Good R. A. Thymoma. Ann Intern Med. 1966 Sep;65(3):607–611. doi: 10.7326/0003-4819-65-3-607. [DOI] [PubMed] [Google Scholar]
  10. Murray W. D., Webb J. N. Thymoma associated with hypogammaglobulinaemia and pure red cell aplasia. Am J Med. 1966 Dec;41(6):974–980. doi: 10.1016/0002-9343(66)90054-4. [DOI] [PubMed] [Google Scholar]
  11. PAUL W. E., COHEN A. S. ELECTRON MICROSCOPIC STUDIES OF AMYLOID FIBRILS WITH FERRITINCONJUGATED ANTIBODY. Am J Pathol. 1963 Oct;43:721–738. [PMC free article] [PubMed] [Google Scholar]
  12. SOOTHILL J. F. The concentration of gamma-globulin and gamma-macroglobulin in the serum of patients with hypogammaglobulinaemia. Proc R Soc Med. 1962 May;55:395–397. doi: 10.1177/003591576205500514. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Schultz R. T., Calkins E., Milgrom F., Witebsky E. Association of gamma globulin with amyloid. Am J Pathol. 1966 Jan;48(1):1–17. [PMC free article] [PubMed] [Google Scholar]
  14. Sutherland D. E., Archer O. K., Peterson R. D., Eckert E., Good R. A. Development of "autoimmune processes" in rabbits after neonatal removal of central lymphoid tissue. Lancet. 1965 Jan 16;1(7377):130–133. doi: 10.1016/s0140-6736(65)91091-3. [DOI] [PubMed] [Google Scholar]
  15. TEILUM G. AMYLOIDOSIS SECONDARY TO AGAMMAGLOBULINAEMIA. J Pathol Bacteriol. 1964 Jul;88:317–320. doi: 10.1002/path.1700880143. [DOI] [PubMed] [Google Scholar]

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