Abstract
Trimethoprim is a synthetic compound which arrests the step in bacterial purine synthesis immediately succeeding that interfered with by sulphonamides.
Acting alone it inhibits the growth of a wide range of bacteria in generally much lower concentrations than sulphonamides. Its action with a sulphonamide is strongly synergic and bactericidal.
Studies are described of suitable cultural conditions, methods of testing sensitivity, and acquired resistance.
Some clinical results of its use are reported in respiratory tract infections, Gram-negative septicaemia, and urinary tract infections, and further therapeutic possibilities are discussed.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- COOPER R. G., WALD M. SUCCESSFUL TREATMENT OF PROTEUS SEPTICAEMIA WITH A NEW DRUG TRIMETHOPRIM. Med J Aust. 1964 Jul 18;2:93–96. [PubMed] [Google Scholar]
- Csonka G. W., Knight G. J. Therapeutic trial of trimethoprim as a potentiator of sulphonamides in gonorrhoea. Br J Vener Dis. 1967 Sep;43(3):161–165. doi: 10.1136/sti.43.3.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Noall E. W., Sewards H. F., Waterworth P. M. Successful Treatment of a Case of Proteus Septicaemia. Br Med J. 1962 Oct 27;2(5312):1101–1102. doi: 10.1136/bmj.2.5312.1101. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROTH B., FALCO E. A., HITCHINGS G. H., BUSHBY S. R. 5-BENZYL-2,4-DIAMINOPYRIMIDINES AS ANTIBACTERIAL AGENTS. I. SYNTHESIS AND ANTIBACTERIAL ACTIVITY IN VITRO. J Med Pharm Chem. 1962 Nov;91:1103–1123. doi: 10.1021/jm01241a004. [DOI] [PubMed] [Google Scholar]
- SCHNEIDER M., SCHWARZENBERG L., CATTAN A., SCHLUMBERGER J. R., AMIEL J. L., MATHE G. ESSAI DE TRAITEMENT DE DIVERSES IN FECTIONS 'A "PROTEUS" PAR LE 2,4-DIAMINO-5-(3,4,5-TRIM'ETHOXYBENZYL) PYRIMIDINE, OU (TRIM'ETHOPRIME) Presse Med. 1965 Mar 27;73:893–894. [PubMed] [Google Scholar]