Abstract
Studies on community acquired pneumonia in the United States in patients over the age of 65 years have shown that Gram negative bacilli account for an appreciable proportion of cases, in addition to usual pathogens such as Streptococcus pneumoniae and Haemophilus influenzae. There have been no reports of community acquired pneumonia in the elderly in the United Kingdom. We undertook such a study to determine the clinical features, aetiology, and outcome. Seventy three patients (38 men) with ages ranging from 65 to 97 (median 79) years were studied prospectively. Pneumonia was defined as an acute lower respiratory tract infection with new, previously unrecorded shadowing on a chest radiograph. Patients with severe chronic illness in whom pneumonia was an expected terminal event were excluded. Nearly all the patients (96%) had respiratory symptoms or signs but many had features that might obscure the true diagnosis of pneumonia. Over half the patients had non-respiratory symptoms and over a third had no systemic signs of infection. A pathogen was identified in 43% of patients, most commonly Streptococcus pneumoniae, Haemophilus influenzae and influenza B virus. Gram negative bacilli were not seen. The mortality rate was high (33%). Early deaths were due to infection whereas later deaths were associated with other factors, such as stroke (two patients) and pulmonary embolism (two patients). Prognostic indicators for mortality were apyrexia, systolic hypotension, increasing hypoxaemia, and new urinary incontinence. As the range of pathogens causing pneumonia was the same in the elderly in this study as in other age groups it is suggested that initial antibiotic treatment for patients in this age group should always cover S pneumoniae and H influenzae.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ebright J. R., Rytel M. W. Bacterial pneumonia in the elderly. J Am Geriatr Soc. 1980 May;28(5):220–223. doi: 10.1111/j.1532-5415.1980.tb00523.x. [DOI] [PubMed] [Google Scholar]
- Lowe G. D. Anticoagulant drugs in the elderly: valuable in selected patients. BMJ. 1988 Nov 12;297(6658):1260, 1262-3. doi: 10.1136/bmj.297.6658.1260. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Macfarlane J. T., Finch R. G., Ward M. J., Macrae A. D. Hospital study of adult community-acquired pneumonia. Lancet. 1982 Jul 31;2(8292):255–258. doi: 10.1016/s0140-6736(82)90334-8. [DOI] [PubMed] [Google Scholar]
- Macfarlane J. T., Ward M. J. Transtracheal injection of saline in the investigation of pneumonia. Br Med J (Clin Res Ed) 1984 Mar 31;288(6422):974–975. doi: 10.1136/bmj.288.6422.974-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Macfarlane J. Community-acquired pneumonia. Br J Dis Chest. 1987 Apr;81(2):116–127. doi: 10.1016/0007-0971(87)90128-8. [DOI] [PubMed] [Google Scholar]
- Starczewski A. R., Allen S. C., Vargas E., Lye M. Clinical prognostic indices of fatality in elderly patients admitted to hospital with acute pneumonia. Age Ageing. 1988 May;17(3):181–186. doi: 10.1093/ageing/17.3.181. [DOI] [PubMed] [Google Scholar]
- Valenti W. M., Trudell R. G., Bentley D. W. Factors predisposing to oropharyngeal colonization with gram-negative bacilli in the aged. N Engl J Med. 1978 May 18;298(20):1108–1111. doi: 10.1056/NEJM197805182982002. [DOI] [PubMed] [Google Scholar]
- Verghese A., Berk S. L. Bacterial pneumonia in the elderly. Medicine (Baltimore) 1983 Sep;62(5):271–285. doi: 10.1097/00005792-198309000-00002. [DOI] [PubMed] [Google Scholar]
- White R. J., Blainey A. D., Harrison K. J., Clarke S. K. Causes of pneumonia presenting to a district general hospital. Thorax. 1981 Aug;36(8):566–570. doi: 10.1136/thx.36.8.566. [DOI] [PMC free article] [PubMed] [Google Scholar]
- White R. T. Pneumococcal vaccine. Thorax. 1988 May;43(5):345–348. doi: 10.1136/thx.43.5.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woodhead M. A., Macfarlane J. T., McCracken J. S., Rose D. H., Finch R. G. Prospective study of the aetiology and outcome of pneumonia in the community. Lancet. 1987 Mar 21;1(8534):671–674. doi: 10.1016/s0140-6736(87)90430-2. [DOI] [PubMed] [Google Scholar]