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. 1990 Apr;45(4):267–271. doi: 10.1136/thx.45.4.267

Hard metal asthma: cross immunological and respiratory reactivity between cobalt and nickel?

T Shirakawa 1, Y Kusaka 1, N Fujimura 1, M Kato 1, S Heki 1, K Morimoto 1
PMCID: PMC473770  PMID: 2356553

Abstract

Eight asthmatic patients with hard metal asthma due to cobalt underwent bronchial provocation challenge with nickel sulphate. Seven patients developed a fall in FEV1 of 20% or more after inhaling nickel sulphate, four showing an immediate response and three a late response. Eight control subjects, including six asthmatic patients, with no history of hard metal exposure, showed no bronchoconstriction in response to a provocation challenge with nickel sulphate. Specific antibodies to nickel conjugated human serum albumin were present in four of the eight patients with sensitivity to cobalt conjugated human serum albumin but were absent from the serum of 60 unexposed asthmatic patients and 25 exposed symptom free workers. These results suggest that nickel as well as cobalt sensitivity plays a part in hard metal asthma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Block G. T., Yeung M. Asthma induced by nickel. JAMA. 1982 Mar 19;247(11):1600–1602. [PubMed] [Google Scholar]
  2. Bruckner H. C. Extrinsic asthma in a tungsten carbide worker. J Occup Med. 1967 Oct;9(10):518–519. doi: 10.1097/00043764-196710000-00006. [DOI] [PubMed] [Google Scholar]
  3. Butcher B. T., O'Neil C. E., Reed M. A., Salvaggio J. E. Radioallergosorbent testing of toluene diisocyanate-reactive individuals using p-tolyl isocyanate antigen. J Allergy Clin Immunol. 1980 Sep;66(3):213–216. doi: 10.1016/0091-6749(80)90041-x. [DOI] [PubMed] [Google Scholar]
  4. Cullen M. R. Respiratory diseases from hard metal exposure. A continuing enigma. Chest. 1984 Oct;86(4):513–514. doi: 10.1378/chest.86.4.513. [DOI] [PubMed] [Google Scholar]
  5. Davies J. E. Occupational asthma caused by nickel salts. J Soc Occup Med. 1986 Spring;36(1):29–31. [PubMed] [Google Scholar]
  6. Davison A. G., Haslam P. L., Corrin B., Coutts I. I., Dewar A., Riding W. D., Studdy P. R., Newman-Taylor A. J. Interstitial lung disease and asthma in hard-metal workers: bronchoalveolar lavage, ultrastructural, and analytical findings and results of bronchial provocation tests. Thorax. 1983 Feb;38(2):119–128. doi: 10.1136/thx.38.2.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Demedts M., Gheysens B., Nagels J., Verbeken E., Lauweryns J., van den Eeckhout A., Lahaye D., Gyselen A. Cobalt lung in diamond polishers. Am Rev Respir Dis. 1984 Jul;130(1):130–135. doi: 10.1164/arrd.1984.130.1.130. [DOI] [PubMed] [Google Scholar]
  8. Dolovich J., Evans S. L., Nieboer E. Occupational asthma from nickel sensitivity: I. Human serum albumin in the antigenic determinant. Br J Ind Med. 1984 Feb;41(1):51–55. doi: 10.1136/oem.41.1.51. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fregert S., Rorsman H. Allergy to chromium, nickel and cobalt. Acta Derm Venereol. 1966;46(2):144–148. [PubMed] [Google Scholar]
  10. Gaul J. E. Development of allergic nickel dermatitis from earrings. JAMA. 1967 Apr 10;200(2):176–178. [PubMed] [Google Scholar]
  11. Gheysens B., Auwerx J., Van den Eeckhout A., Demedts M. Cobalt-induced bronchial asthma in diamond polishers. Chest. 1985 Nov;88(5):740–744. doi: 10.1378/chest.88.5.740. [DOI] [PubMed] [Google Scholar]
  12. Hargreave F. E., Ryan G., Thomson N. C., O'Byrne P. M., Latimer K., Juniper E. F., Dolovich J. Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance. J Allergy Clin Immunol. 1981 Nov;68(5):347–355. doi: 10.1016/0091-6749(81)90132-9. [DOI] [PubMed] [Google Scholar]
  13. Hartmann A., Wüthrich B., Bolognini G. Berufsbedingte Lungenkrankheiten bei der Hartmetallproduktion und -bearbeitung. Ein allergisches Geschehen? Schweiz Med Wochenschr. 1982 Aug 14;112(33):1137–1141. [PubMed] [Google Scholar]
  14. Kroon S. Standard photopatch testing with Musk Ambrette. Contact Dermatitis. 1983 Jan;9(1):1–4. doi: 10.1111/j.1600-0536.1983.tb04618.x. [DOI] [PubMed] [Google Scholar]
  15. Kusaka Y., Yokoyama K., Sera Y., Yamamoto S., Sone S., Kyono H., Shirakawa T., Goto S. Respiratory diseases in hard metal workers: an occupational hygiene study in a factory. Br J Ind Med. 1986 Jul;43(7):474–485. doi: 10.1136/oem.43.7.474. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Malo J. L., Cartier A., Doepner M., Nieboer E., Evans S., Dolovich J. Occupational asthma caused by nickel sulfate. J Allergy Clin Immunol. 1982 Jan;69(1 Pt 1):55–59. doi: 10.1016/0091-6749(82)90088-4. [DOI] [PubMed] [Google Scholar]
  17. Malo J. L., Cartier A., Gagnon G., Evans S., Dolovich J. Isolated late asthmatic reaction due to nickel sulphate without antibodies to nickel. Clin Allergy. 1985 Mar;15(2):95–99. doi: 10.1111/j.1365-2222.1985.tb02261.x. [DOI] [PubMed] [Google Scholar]
  18. Menne T. Relationship between cobalt and nickel sensitization in females. Contact Dermatitis. 1980 Aug;6(5):337–340. doi: 10.1111/j.1600-0536.1980.tb04959.x. [DOI] [PubMed] [Google Scholar]
  19. Nieboer E., Evans S. L., Dolovich J. Occupational asthma from nickel sensitivity: II. Factors influencing the interaction of Ni2+, HSA, and serum antibodies with nickel related specificity. Br J Ind Med. 1984 Feb;41(1):56–63. doi: 10.1136/oem.41.1.56. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Novey H. S., Habib M., Wells I. D. Asthma and IgE antibodies induced by chromium and nickel salts. J Allergy Clin Immunol. 1983 Oct;72(4):407–412. doi: 10.1016/0091-6749(83)90507-9. [DOI] [PubMed] [Google Scholar]
  21. Rizzato G., Lo Cicero S., Barberis M., Torre M., Pietra R., Sabbioni E. Trace of metal exposure in hard metal lung disease. Chest. 1986 Jul;90(1):101–106. doi: 10.1378/chest.90.1.101. [DOI] [PubMed] [Google Scholar]
  22. Rizzato G., Lo Cicero S., Barberis M., Torre M., Pietra R., Sabbioni E. Trace of metal exposure in hard metal lung disease. Chest. 1986 Jul;90(1):101–106. doi: 10.1378/chest.90.1.101. [DOI] [PubMed] [Google Scholar]
  23. Rosenthal R. R. The emerging role of bronchoprovocation. J Allergy Clin Immunol. 1979 Dec;64(6 Pt 2):564–568. doi: 10.1016/0091-6749(79)90013-7. [DOI] [PubMed] [Google Scholar]
  24. Roto P. Asthma, symptoms of chronic bronchitis and ventilatory capacity among cobalt and zinc production workers. Scand J Work Environ Health. 1980;6 (Suppl 1):1–49. [PubMed] [Google Scholar]
  25. Ryan G., Dolovich M. B., Obminski G., Cockcroft D. W., Juniper E., Hargreave F. E., Newhouse M. T. Standardization of inhalation provocation tests: influence of nebulizer output, particle size, and method of inhalation. J Allergy Clin Immunol. 1981 Feb;67(2):156–161. doi: 10.1016/0091-6749(81)90012-9. [DOI] [PubMed] [Google Scholar]
  26. Rystedt I., Fischer T. Relationship between nickel and cobalt sensitization in hard metal workers. Contact Dermatitis. 1983 May;9(3):195–200. doi: 10.1111/j.1600-0536.1983.tb04357.x. [DOI] [PubMed] [Google Scholar]
  27. SCHEPERS G. W. The biological action of tungsten carbide and cobalt; studies on experimental pulmonary histopathology. AMA Arch Ind Health. 1955 Aug;12(2):140–146. [PubMed] [Google Scholar]
  28. Shirakawa T., Kusaka Y., Fujimura N., Goto S., Kato M., Heki S., Morimoto K. Occupational asthma from cobalt sensitivity in workers exposed to hard metal dust. Chest. 1989 Jan;95(1):29–37. doi: 10.1378/chest.95.1.29. [DOI] [PubMed] [Google Scholar]
  29. Shirakawa T., Kusaka Y., Fujimura N., Goto S., Morimoto K. The existence of specific antibodies to cobalt in hard metal asthma. Clin Allergy. 1988 Sep;18(5):451–460. doi: 10.1111/j.1365-2222.1988.tb02895.x. [DOI] [PubMed] [Google Scholar]
  30. Sjögren I., Hillerdal G., Andersson A., Zetterström O. Hard metal lung disease: importance of cobalt in coolants. Thorax. 1980 Sep;35(9):653–659. doi: 10.1136/thx.35.9.653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Venezia C., Karol M. H. Comparison of cobalt and chromium binding to blood elements. Toxicology. 1984 Mar;30(2):125–133. doi: 10.1016/0300-483x(84)90123-9. [DOI] [PubMed] [Google Scholar]

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