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. 1968 May;21(3):353–358. doi: 10.1136/jcp.21.3.353

Tubular reabsorption of calcium in normal and hypercalciuric subjects

M Peacock 1,2, B E C Nordin 1,2
PMCID: PMC473795  PMID: 5699075

Abstract

Tubular reabsorption and excretion of calcium were studied at different levels of filtered calcium by means of calcium infusion in normal and hypercalciuric subjects and in patients with idiopathic nephrolithiasis.

Calcium reabsorption and excretion rose linearly with filtered load and in no case was a maximum tubular reabsorptive capacity for calcium reached.

No decrease in tubular reabsorption of calcium was found in hypercalciuric as compared with normocalciuric subjects, and no difference in tubular reabsorption was found between patients with idiopathic nephrolithiasis and normal subjects.

Calcium excretion and reabsorption calculated from the endogenous creatinine clearance during calcium infusion were virtually identical with the corresponding values calculated from the inulin clearance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERLYNE G. M., VARLEY H., NILWARANGKUR S., HOERNI M. ENDOGENOUS-CREATININE CLEARANCE AND GLOMERULAR-FILTRATION RATE. Lancet. 1964 Oct 24;2(7365):874–876. doi: 10.1016/s0140-6736(64)90735-4. [DOI] [PubMed] [Google Scholar]
  2. CANIGGIA A., GENNARI C., CESARI L. INTESTINAL ABSORPTION OF 45CA IN STONE-FORMING PATIENTS. Br Med J. 1965 Feb 13;1(5432):427–429. doi: 10.1136/bmj.1.5432.427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CHEN P. S., Jr, NEUMAN W. F. Renal excretion of calcium by the dog. Am J Physiol. 1955 Mar;180(3):623–631. doi: 10.1152/ajplegacy.1955.180.3.623. [DOI] [PubMed] [Google Scholar]
  4. COPP D. H., McPHERSON G. D., McINTOSH H. W. Renal excretion of calcium in man: estimation of Tm-Ca. Metabolism. 1960 Jul;9:680–685. [PubMed] [Google Scholar]
  5. DOOLAN P. D., ALPEN E. L., THEIL G. B. A clinical appraisal of the plasma concentration and endogenous clearance of creatinine. Am J Med. 1962 Jan;32:65–79. doi: 10.1016/0002-9343(62)90183-3. [DOI] [PubMed] [Google Scholar]
  6. Edwards N. A., Hodgkinson A. Studies of renal function in patients with idiopathic hypercalciuria. Clin Sci. 1965 Oct;29(2):327–338. [PubMed] [Google Scholar]
  7. FALES F. W. EVALUATION OF PROCEDURES FOR URINARY CALCIUM. Clin Chem. 1964 Jun;10:549–558. [PubMed] [Google Scholar]
  8. HENNEMAN P. H., BENEDICT P. H., FORBES A. P., DUDLEY H. R. Idiopathic hypercaicuria. N Engl J Med. 1958 Oct 23;259(17):802–807. doi: 10.1056/NEJM195810232591702. [DOI] [PubMed] [Google Scholar]
  9. HODGKINSON A., PYRAH L. N. The urinary excretion of calcium and inorganic phosphate in 344 patients with calcium stone of renal origin. Br J Surg. 1958 Jul;46(195):10–18. doi: 10.1002/bjs.18004619504. [DOI] [PubMed] [Google Scholar]
  10. JACKSON W. P., DANCASTER C. A consideration of the hypercalciuria in sarcoidosis, idiopathic hypercalciuria, and that produced by vitamin D; a new suggestion regarding calcium metabolism. J Clin Endocrinol Metab. 1959 Jun;19(6):658–680. doi: 10.1210/jcem-19-6-658. [DOI] [PubMed] [Google Scholar]
  11. KESSLER G., WOLFMAN M. AN AUTOMATED PROCEDURE FOR THE SIMULTANEOUS DETERMINATION OF CALCIUM AND PHOSPHORUS. Clin Chem. 1964 Aug;10:686–703. [PubMed] [Google Scholar]
  12. Malamos B., Dontas A. S., Koutras D. A., Marketos S., Sfontouris J., Papanicolaou N. The determination of glomerular filtration-rate in clinical practice. Lancet. 1966 Apr 30;1(7444):943–945. doi: 10.1016/s0140-6736(66)90946-9. [DOI] [PubMed] [Google Scholar]
  13. Pitts R. F., Ayer J. L., Schiess W. A., Miner P. THE RENAL REGULATION OF ACID-BASE BALANCE IN MAN. III. THE REABSORPTION AND EXCRETION OF BICARBONATE. J Clin Invest. 1949 Jan;28(1):35–44. doi: 10.1172/JCI102050. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. TOBIAS G. J., McLAUGHLIN R. F., Jr, HOPPER J., Jr Endogenous creatinine clearance. A valuable clinical test of glomerular filtration and a prognostic guide in chronic renal disease. N Engl J Med. 1962 Feb 15;266:317–323. doi: 10.1056/NEJM196202152660701. [DOI] [PubMed] [Google Scholar]
  15. TORIBARA T. Y., TEREPKA A. R., DEWEY P. A. The ultrafiltrable calcium of human serum. I. Ultrafiltration methods and normal values. J Clin Invest. 1957 May;36(5):738–748. doi: 10.1172/JCI103477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. WALSER M., BROWDER A. A. Ion association. III. The effect of sulfate infusion on calcium excretion. J Clin Invest. 1959 Aug;38(8):1404–1411. doi: 10.1172/JCI103916. [DOI] [PMC free article] [PubMed] [Google Scholar]

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