Abstract
This paper reports the results of estimating vitamin B12 absorption by whole body counting in patients without known gastrointestinal disorder, and in patients with pernicious anaemia, idiopathic achlorhydria, achlorhydria following gastric operations, and various forms of small intestinal disease. Patients with pernicious anaemia absorbed less than 30% of the test dose; they could be distinguished from patients without gastrointestinal abnormality and from most achlorhydric patients who secreted more than 300 mg units of intrinsic factor in the post-histamine hour. Nevertheless, the wide range of normal absorption and the variable absorption from the normal gastrointestinal tract is emphasized and discussed. There is no relation between histamine-stimulated intrinsic factor production and vitamin B12 absorption in patients with small intestinal disease.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ADAMS J. F., CARTWRIGHT E. J. The reliability and reproducibility of the Schilling test in primary malabsorptive disease and after partial gastrectomy. Gut. 1963 Mar;4:32–36. doi: 10.1136/gut.4.1.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ARDEMAN S., CHANARIN I. A METHOD FOR THE ASSAY OF HUMAN GASTRIC INTRINSIC FACTOR AND FOR THE DETECTION AND TITRATION OF ANTIBODIES AGAINST INTRINSIC FACTOR. Lancet. 1963 Dec 28;2(7322):1350–1354. doi: 10.1016/s0140-6736(63)90736-0. [DOI] [PubMed] [Google Scholar]
- Callender S. T., Witts L. J., Warner G. T., Oliver R. The use of a simple whole-body counter for haematological investigations. Br J Haematol. 1966 May;12(3):276–282. doi: 10.1111/j.1365-2141.1966.tb05634.x. [DOI] [PubMed] [Google Scholar]
- KAY A. W. Effect of large doses of histamine on gastric secretion of HCI; an augmented histamine test. Br Med J. 1953 Jul 11;2(4827):77–80. doi: 10.1136/bmj.2.4827.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rune S. J. Comparison of the rates of gastric acid secretion in man after ingestion of food and after maximal stimulation with histamine. Gut. 1966 Aug;7(4):344–350. doi: 10.1136/gut.7.4.344. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shearman D. J., Finlayson N. D., Wilson R. Gastric function in patients with gastric carcinoma. Lancet. 1967 Feb 18;1(7486):343–346. doi: 10.1016/s0140-6736(67)92892-9. [DOI] [PubMed] [Google Scholar]