Abstract
The case of a patient with cirrhosis of the liver suffering from severe haemolysis accompanied by circulating `spur cells' is described. Studies performed in an attempt to determine the cause for the abnormal shape of the erythrocytes demonstrated that the patient's serum could induce spur formation in normal compatible cells. Several lines of evidence pointed to the possibility that the factor inducing the spurs was a protein. By column chromatography and gradient ultracentrifugation it was shown that the patient's low density lipoproteins could induce spurs to form in normal cells.
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- BASSEN F. A., KORNZWEIG A. L. Malformation of the erythrocytes in a case of atypical retinitis pigmentosa. Blood. 1950 Apr;5(4):381–387. [PubMed] [Google Scholar]
- BRAIN M. C., DACIE J. V., HOURIHANE D. O. Microangiopathic haemolytic anaemia: the possible role of vascular lesions in pathogenesis. Br J Haematol. 1962 Oct;8:358–374. doi: 10.1111/j.1365-2141.1962.tb06541.x. [DOI] [PubMed] [Google Scholar]
- JANDL J. H. The anemia of liver disease: observations on its mechanism. J Clin Invest. 1955 Mar;34(3):390–404. doi: 10.1172/JCI103087. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KIMBER C., DELLER D. J., IBBOTSON R. N., LANDER H. THE MECHANISM OF ANAEMIA IN CHRONIC LIVER DISEASE. Q J Med. 1965 Jan;34:33–64. [PubMed] [Google Scholar]
- RIVERA J. V., TORO-GOYCO E., MATOS M. L. MOLECULAR SIEVE IN THE STUDY OF PLASMA PROTEINS. Am J Med Sci. 1965 Apr;249:371–377. doi: 10.1097/00000441-196504000-00001. [DOI] [PubMed] [Google Scholar]
- SALT H. B., WOLFF O. H., LLOYD J. K., FOSBROOKE A. S., CAMERON A. H., HUBBLE D. V. On having no beta-lipoprotein. A syndrome comprising a-beta-lipoproteinaemia, acanthocytosis, and steatorrhoea. Lancet. 1960 Aug 13;2(7146):325–329. doi: 10.1016/s0140-6736(60)91478-1. [DOI] [PubMed] [Google Scholar]
- SCHWARTZ S. O., MOTTO S. A. The diagnostic significance of burr red blood cells. Am J Med Sci. 1949 Nov;218(5):563–566. doi: 10.1097/00000441-194911000-00012. [DOI] [PubMed] [Google Scholar]
- SILVERSTEIN E. Peripheral venous oxygen saturation in patients with and without liver disease. J Lab Clin Med. 1956 Apr;47(4):513–518. [PubMed] [Google Scholar]
- SIMON E. R., WAYS P. INCUBATION HEMOLYSIS AND RED CELL METABOLISM IN ACANTHOCYTOSIS. J Clin Invest. 1964 Jul;43:1311–1321. doi: 10.1172/JCI105006. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SMITH J. A., LONERGAN E. T., STERLING K. SPUR-CELL ANEMIA: HEMOLYTIC ANEMIA WITH RED CELLS RESEMBLING ACANTHOCYTES IN ALCOHOLIC CIRRHOSIS. N Engl J Med. 1964 Aug 20;271:396–398. doi: 10.1056/NEJM196408202710804. [DOI] [PubMed] [Google Scholar]
- Silber R., Amorosi E., Lhowe J., Kayden H. J. Spur-shaped erythrocytes in Laennec's cirrhosis. N Engl J Med. 1966 Sep 22;275(12):639–643. doi: 10.1056/NEJM196609222751204. [DOI] [PubMed] [Google Scholar]
- ZAK B. Simple rapid microtechnic for serum total cholesterol. Am J Clin Pathol. 1957 May;27(5):583–588. doi: 10.1093/ajcp/27.5_ts.583. [DOI] [PubMed] [Google Scholar]