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(A) Whole-cell currents evoked by ATP (at saturating concentrations) from HEK cells expressing the wild-type (WT) P2X2 receptor (1000 μM), G342P (100 μM) or G324A (1000 μM) mutant. (B) Concentration-response relationships for ATP at WT P2X2 receptor and mutant receptors, as indicated (n = 4–6 cells; mean ± s.e.m.). The Hill equation was fit to the normalized data.
