Urodynamic and physiologic patterns associated with the common causes of neurogenic bladder in adults

Abstract

The clinical presentation of the neurogenic bladder can be as vast as the pathologic causes however urodynamics (UDS) can help guide clinical decision-making and help simplify a complex disease state. UDS may be considered as the gold standard in helping to break down complex and multifactorial voiding dysfunction into manageable goals; these include protecting the upper tracts, limiting urinary tract infections (UTI) via avoiding urinary stasis, and maintaining quality of life. Included within are examples of normal to pathologic tracings including normal filling and voiding, detrusor sphincteric coordination, changes in compliance, etc. Additionally we have provided expected UDS findings based on neurogenic disease process, including but not limited to, Parkinson’s, dementia, multiple sclerosis (MS) and spinal cord injury based on lesion location. Pattern recognition and understanding of UDS can help lead to quality of life improvements and optimal management for the patient with neurogenic bladder dysfunction.

Introduction

Complete evaluation of the patient with neurologic bladder dysfunction is important for goal oriented treatments. Although the causes of the dysfunction and their subsequent effects can be vast, with appropriate evaluation, the clinician can break these down into basic and treatable factors. These factors include function or dysfunction of storage, detrusor activity, and pelvic floor response. Urodynamics (UDS) may be considered as the gold standard in helping to break down complex and multifactorial voiding dysfunction into manageable headings; these include protecting the upper tracts, limiting urinary tract infections (UTI) via avoiding urinary stasis, and maintaining quality of life. Experts believe all neurogenic patients should undergo a baseline UDS study and as needed for any clinical changes or new symptoms (1,2). Herein we outline the basic elements seen in patients with neurogenic bladder on UDS, and augment these with examples of lesions, for any cause, at clinically relevant levels of the neurologic pathway.

Non-invasive UDS

Non-invasive UDS are inexpensive, readily available, have low morbidity and are a great option for an initial evaluation. Post-void residuals (PVR) and uroflowmetry are the keystones of this evaluation. Using ultrasound the bladder can be scanned after a void to estimate a residual volume. Many experts believe that a PVR of <100–200 indicates acceptable emptying to prevent infection and normal detrusor function (3). Uroflowmetry is the measurement of voided urine over the course of time and can be calculated and compared to established nomograms (4). For abnormal findings these studies have their limitations in isolating elements of the voiding cycle that may be malfunctioning such as detrusor vs. pelvic floor dysfunction or outlet issues. The combination of these two studies plays an important role for initial evaluation prior to invasive UDS evaluation and after treatment as a low cost and well tolerated set of tools.

Invasive UDS

For the patient with neurologic voiding dysfunction, invasive UDS may be the most powerful and helpful assessment tool set. The basis of an invasive urodynamic study is obtaining pressure readings and myogenic readings of the pelvic floor with the use of specifically placed catheters and electrodes. This information helps give a graphical interpretation of pressures within and produced by the bladder, abdominal cavity, and the pelvic floor musculature (Figure 1). A pressure sensing catheter is placed in the bladder and the rectum. These values, along with the electromyography (EMG), can help give a physiologic description of the dynamics in the phases of filling, storage, and voiding.

Figure 1.

Schematic showing the determination of detrusor pressure or Pdet. The detrusor contribution to voiding is calculated by subtracting the abdominal pressure (Pabd; estimated as rectal pressure) from total intravesical pressure (Pves).

Components of the urodynamic evaluation

Filling/storage

Patients with neurologic bladder dysfunction may have a wide array of storage capacity abnormalities ranging from very small volumes to large distended bladders. Typical adult bladders have a capacity of 300–600 cc (5). Decreased volumes can cause frequency and make incontinence worse whereas large volumes can contribute to urinary stasis and increase the risk of UTI.

Compliance

Compliance is calculated by the change in volume divided by the change in pressure (Table 1). This represents the bladder’s ability to maintain storage at low pressures as the bladder fills. These measurements rely on accurate recording of the rectal pressure/abdominal pressure (Pabd) and intravesical pressure (Pves), which together allow one to calculate the detrusor pressure (Pdet), with Pves – Pabd = Pdet. A physiologically normal bladder has a relatively constant low bladder pressure throughout the filling cycle, resulting in a high compliance. A normal compliance can reach infinity and an abnormal compliance is variably defined as <40 or <20 cc/cmH₂O. Decreased compliance, or sustained Pdet greater than 40 cmH₂O, can put the upper tracts at risk for elevated pressures resulting in renal atrophy and infection risk.

Table 1. UDS key terminology as defined by the International Continence Society (6).

Term	Definition (as defined by the International Continence Society) (6)
Compliance	The relationship between change in bladder volume and change in detrusor pressure (∆V/∆P)
Normal bladder sensation	Judged by three defined points noted during filling cystometry and evaluated in relation to the bladder volume at that moment in relation to the patient’s symptomatic complaints:
	I. First sensation of bladder filling is the feeling the patient has, during filling cystometry, when he/she first becomes aware of the bladder filling
	II. First desire to void is defined as the feeling, during filling cystometry, that would lead the patient to pass urine at the next convenient moment, but voiding can be delayed if necessary
	III. Strong desire to void is defined, during filling cystometry, as the persistent desire to void without fear of leakage
Normal detrusor function	Normal bladder filling has little or no change in pressure and no involuntary phasic contractions occur despite provocation. Normal voiding is achieved by a voluntarily initiated continuous detrusor contraction that leads to complete bladder emptying within a normal time span, and in the absence of obstruction
Abnormal detrusor function	Can be subdivided:
	I. Detrusor underactivity is defined as a contraction of reduced strength and/or duration, result in in prolonged bladder emptying and/or a failure to achieve complete bladder emptying within a normal time span
	II. Acontractile detrusor is one that cannot be demonstrated to contract during urodynamic studies
Detrusor overactivity	Is a UDS observation characterized by involuntary detrusor contractions during the filling phase which may be spontaneous or provoked
Neurogenic detrusor overactivity	Detrusor overactivity accompanied by a neurologic condition. This term replaces detrusor hyperreflexia
Detrusor sphincter dyssynergia	Is defined as a detrusor contraction concurrent with an involuntary contraction of the urethral and/or periurethral striated muscle. Occasionally, flow may be prevented altogether (type III)

UDS, urodynamics.

Bladder sensation (sensory)

Normal bladder sensation can be judged by three defined points noted during the filling cycle and evaluated in relation to the bladder volume (Table 1). In the patient with neurologic bladder dysfunction bladder sensation can be absent, decreased, or heightened. Noting the following, with exact definitions, during the filling cycle can be useful in evaluation:

• First sensation of bladder filling: is the feeling the patient has, during filling cystometry, when he/she first becomes aware of the bladder filling;

• First desire to void: is defined as the feeling, during filling cystometry, that would lead the patient to pass urine at the next convenient moment, but voiding can be delayed if necessary;

• Strong desire to void: a persistent desire to void without fear of leakage (6).

Detrusor function (motor)

Function of the detrusor muscle is comprised of two components, its ability to passively allow filling (compliance) and its ability to contract upon voluntary micturition. This is measured in UDS by Pdet and voided volumes. Decreased relaxation during filling can contribute to storage issues as well as overactivity. Detrusor overactivity (DO) is defined as involuntary detrusor contractions, of variable duration and amplitude, during filling that are unable to be suppressed by the patient (Table 1) (6). DO can contribute to urgency and frequency, incontinence at low storage volumes, and elevated pressures if not coordinated with sphincteric relaxation during micturition (see below). Poor contraction at large volumes can decrease or eliminate the patient’s ability to void to completion thus contributing to an ever increasing volume, and possible increased risk of urinary retention and upper tract deterioration over time.

Sphincter activity

This represents the external urinary sphincter’s ability to maintain contraction and relaxation at appropriate times throughout the filling and voiding cycle (Table 1). This is measured in UDS by the EMG tracing. A normal sphincter mechanism shows activity as manifested by increased recruitment during the filling cycle, increasing as the bladder volume increases to maintain continence. Failure of the sphincter to maintain contraction leads to incontinence and low pressures/volumes of leaking. During the voiding cycle, or during a coordinated detrusor contraction, one normally sees silence of the sphincteric myogenic activity or relaxation (7).

A common finding in patients with neurologic bladder dysfunction is discoordination of the sphincter during contraction [detrusor sphincter dyssynergia (DSD)] (Table 2) (9). By setting up a situation where the bladder contracts against a non-coordinated closed sphincter, this may over time, create high Pves putting the upper tracts at risk for deterioration (10). There are three main types of DSD (Figure 2). In type I there is a synchronous increase in the Pdet and sphincteric tone until the peak of detrusor function at which point the sphincteric tone relaxes and unobstructed voiding occurs. Type II DSD is characterized by sporadic contractions of the sphincter throughout the detrusor function. Type III DSD is similar to type I in which the sphincteric tone increases throughout the detrusor function however, contrary to type I, relaxation is never observed and results in obstructed voiding. Patients with type III DSD are at highest risk for upper tract deterioration due to elevated pressures during micturition and decreased voided volumes.

Table 2. Lesion specific neurogenic bladder dysfunction.

Lesion location	Common UDS findings
Suprapontine lesions (central—upper motor neuron)	Detrusor overactivity without detrusor sphincter dyssynergy. Sphincter will relax during bladder contraction and bladder sensation is often intact (8)
Suprasacral lesions	Combination of DO and DESD which is intermittent or complete failure of relaxation of urinary sphincter during contraction/voiding (1). High intravesical voiding pressures in order to overcome the contraction of the external sphincter. Upper tract deterioration
Sacral lesions	Highly compliant acontractile bladder (1). External sphincter is functional; therefore continence is conserved. Good CIC candidates

UDS, urodynamics; DO, detrusor overactivity; DESD, detrusor external sphincter dyssynergia; CIC, clean intermittent catheterization.

Figure 2.

Three types of DSD. The top line shows a Pdet tracing during an attempted void while the bottom line shows EMG activity. Type I shows a temporary failure of the EMG to silence during contraction while type II is intermittent but not obstructing. Type III shows a crescendo of the EMG throughout the detrusor function. DSD, detrusor sphincter dyssynergia; Pdet, detrusor pressure; EMG, electromyography.

Patterns of voiding dysfunction with fixed lesions

Urinary dysfunction is common with fixed lesion spinal cord injury with approximately 81% of patients having some element of voiding dysfunction (11). The degree of UDS findings and voiding dysfunction can fall into three categories based the level of the neurologic lesion; suprapontine (central—upper motor neuron), suprasacral, and sacral lesions (Figure 3). Based on these levels capacity, compliance, contractility, and pelvic sphincteric function have predictable patterns on UDS, all of which will help clinicians in the clinical management of the patient (Table 2). In patients with a single level of spinal cord injury the level of injury and the type of voiding dysfunction has a stronger correlation. Patients with combined suprasacral and sacral injuries can have relatively unpredictable urodynamic findings (8). Management of the urinary tract in patients with spinal cord injury must be based on urodynamic findings rather than inferences from the neurologic evaluation. In reality many disease processes will have some elements that do not fall within the simplified groupings outlined for patients with fixed spinal cord defects above. However, again simplifying these complex lesions into three clinically relevant categories can be a useful tool for the clinician in driving realistic and beneficial treatments (1).

Figure 3.

Patterns of voiding dysfunction based on level.

Neurologic bladder dysfunction in specific neurological disorders

Neurologic disorders often do not fit as neatly into predicted patterns of voiding dysfunction as do fixed spinal cord lesions. However there are some predictable findings on UDS which are experienced with increased frequency and will be outlined in the paragraphs below and Table 3.

Table 3. Various disease processes and their associated typical UDS findings.

Disease process	Capacity	Compliance	Detrusor activity	Sphincter function
MS	−	−	+	N, DSD
Parkinson’s	N, −	N, −	+ early, − late	−
Dementia	N	N, −	N	N, −
Spina bifida	+, N, −	+, N, −	+, N, −	−, DSD
Diabetes	N, +	N early, + late	N, −	N, −
Peripheral neuropathy	N, +	N, +	N, −	N, −
CVA	N	N	N, −	N, −

Note this is a generalization and oftentimes clinical correlations represent a combination of these findings (1,9,12,13). N, normal; +, increased; −, decreased; UDS, urodynamics; MS, multiple sclerosis; DSD, detrusor sphincter dyssynergia; CVA, cerebral vascular accident.

Multiple sclerosis (MS)

MS and other demyelinating disorders can have highly variable clinical presentations based on the amount of disease burden. Most commonly UDS tracings will show some element of DO, when combined with decreased capacity and compliance, storage issues can be in the forefront. Each patient should be evaluated for safety of the upper tracts as DSD is common.

Parkinson’s disease (PD)

PD patients generally present with overactive bladder symptoms, neurologic DO on UDS, and urge incontinence. These symptoms are generally uniform early in the disease process for all patients. A subset of the population will have symptoms progress to global hypoactivity with decreased capacity, passive filling resulting in decreased compliance and decreased sphincteric function. Retention generally is not a clinical problem given worsening sphincter tone.

Spina bifida (SB)

Clinical and UDS findings with SB are highly variable. Increases and decreases in capacity, compliance, detrusor activity and sphincteric function can be observed throughout the vast gambit of SB presentations. As such, frequent and repeat UDS with any clinical change has become the corner stone of care. One finding found with increased frequency in the SB population is DSD, often severe, and if gone unidentified can put the patient’s upper tracts at significant risk for deterioration.

Diabetes mellitus (DM) and peripheral neuropathy (PN)

DM and its associated PN, or PN from other causes, can have significant clinical impacts on voiding dysfunction. Clinical symptoms worsen with disease progression and generally include declining detrusor function and over time results in larger bladder volumes, increased compliance. Depending on the degree of decrease in sphincteric function clinical presentation can present at urinary retention, more commonly in men with higher outlet resistance, to incontinence with high residuals in females.

Cerebral vascular accident (CVA)

Clinical presentation can be highly variable with variability in location of the upper motor neurons affected. However, seen with some frequency are detrusor underactivity and incontinence problems with decreased sphincteric function. As in DM and PN the degree of residual volumes can depend on the severity of decreased sphincteric function (1,9,12,13).

Urodynamic tracings and examples of key findings

For reference and clinical comparison outlined below are figures which include urodynamic tracings of normal (Figure 4), three types of DSD (Figures 5,6,7), several categories of neurogenic voiding dysfunction including decreased compliance and detrusor over activity (Figures 8,9,10).

Figure 4.

Normal urodynamics tracing. The bladder slowly fills with no change in detrusor pressure thus exhibiting normal compliance. There are no uninhibited detrusor contractions noted prior to the full void attempt (after permission to urinate was given by the examiner) and thus no DO noted. The EMG shows recruitment leading up to the contraction thus maintaining continence and creating an adequate void pressure but it notably quiets at the peak detrusor pressure allowing an unobstructed coordinated void to completion. DO, detrusor overactivity; EMG, electromyography; Pdet, detrusor pressure; Pves, intravesical pressure; Pabd, abdominal pressure.

Figure 5.

Type I DSD. Patient with normal compliance and a normal capacity of 300 mL. At time of void initiation the EMG shows recruitment however quickly subsides and a voided volume is obtained (type I DSD). Pdet rises to the mid 80 s mmH₂O which is not considered elevated at a time of void. DSD, detrusor sphincter dyssynergia; EMG, electromyography; Pdet, detrusor pressure; Pves, intravesical pressure; Pabd, abdominal pressure.

Figure 6.

Type II DSD. Patient with normal compliance, volumes are small at around 200 mL. At time of void initiation the EMG shows recruitment that is intermittent throughout the void (type II DSD) resulting in a flow with a peak of 12 mL/s. DSD, detrusor sphincter dyssynergia; EMG, electromyography; Pdet, detrusor pressure; Pves, intravesical pressure; Pabd, abdominal pressure.

Figure 7.

Type III DSD. Patient with normal compliance and a decreased capacity of 160 mL. At time of void initiation the EMG shows a crescendo, decrescendo firing pattern throughout the void, elevation of Pdet and with no appreciable voided volume. DSD, detrusor sphincter dyssynergia; EMG, electromyography; Pdet, detrusor pressure; Pves, intravesical pressure; Pabd, abdominal pressure.

Figure 8.

Elevated compliance with an acontractile bladder. Bladder volume rises to approximately 820 mL with minimal change in Pves. Patient is asked to void at a volume of 820 mL with no appreciable detrusor function or change in sphincteric EMG. This pattern of voiding function was taken from a patient with a sacral level lesion. EMG, electromyography; Pdet, detrusor pressure; Pves, intravesical pressure; Pabd, abdominal pressure.

Figure 9.

Detrusor overactivity. Normal compliance with normal to high volume of 700 mL. Frequent uninitiated detrusor contractions throughout the filling period. This pattern is often encountered in Parkinson’s and MS patients. MS, multiple sclerosis; EMG, electromyography; Pdet, detrusor pressure; Pves, intravesical pressure; Pabd, abdominal pressure.

Figure 10.

Low-volume bladder with a loss of compliance. Throughout the filling phase there is consistent rise of Pves and Pdet, despite low volumes of 200 mL, which continue above 50 cmH₂O without an appreciable void attempt. No notable detrusor overactivity or DSD identified. This pattern is often encountered in spina bifida patients. DSD, detrusor sphincter dyssynergia; EMG, electromyography; Pdet, detrusor pressure; Pves, intravesical pressure; Pabd, abdominal pressure.

Summary

The evaluation of a patient with neurogenic bladder dysfunction with UDS provides a powerful tool in the identification of the disease specific manifestation of voiding dysfunction and can create a framework for goal directed management. A full UDS evaluation contributes a baseline with which disease progression can be monitored, and periodic assessment of risk for upper tract deterioration, and identification of clinically beneficial interventions may be performed intermittently as the clinical situation dictates. Patterned findings often correlate to lesion level/location or disease process. Pattern recognition and understanding of UDS can help lead to quality of life improvements and optimal management for the patient with neurogenic bladder dysfunction.