Table 1. IC50 value for monotherapy vs dual therapy.
The concentration of drug where 50% cell death was obtained was compared for mono and dual drug therapy
| Monotherapy | Dual therapy | |||
|---|---|---|---|---|
| Cell line | 1C50 STA μM | 1C50 VER μM | 1C50STA μM | VER μM |
| T24 | 0.6 | 46 | 0.5 | 32 |
| SW780 | 0.4 | 28 | 0.1 | 14 |
| J82 | 0.8 | 44 | 0.1 | 16 |
| UMUC3 | 0.1 | 16 | 0.05 | 14 |
Cells were treated with 1 μM STA9090 and 50 μM VER155008 as mono or concurrent dual therapy and the cell viability determined by MTT assays. The value was determined after 2 hours of treatment.