Table 4. Substrate specificity of some SLC16 family members.
Gene (Alt. name) | Kmpyruvate (mM) | Kmlactate (mM) | Km2-hydroxybutyrate (mM) | Kmacetoacetate (mM) |
---|---|---|---|---|
SLC16A1 (MCT1) | 0.7 | 4.5 | 2.6 | 5.5 |
SLC16A7 (MCT2) | 0.08 | 0.74 | ND | 0.8 |
SLC16A8 (MCT3) | ND | 6 | ND | ND |
SLC16A3 (MCT4) | 153 | 28 | 56 | 216 |
Km values for pyruvate, L-lactate, D,L-2-hydroxybutyrate and acetoacetate are given from [19]. ND – no detectable transport was observed.