Table 1. Patient Demographics and Clinical Characteristics.
Number of patients (tertile of SUVmax-T, SUVmax-N and EBV DNA, n = 874) | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Characteristic | SUVmax-T | P | SUVmax-N | P | EBV DNA, copies/mL | P | ||||||
<10.7 | 10.7–16.1 | ≥16.1 | <5.7 | 5.7–12.3 | ≥12.3 | <629 | 629–9,820 | ≥9,820 | ||||
Age, years | ||||||||||||
Median | 48 | 46 | 48 | 46 | 48 | 47 | 46 | 47 | 48 | |||
Sex | 0.527 | 0.380 | 0.894 | |||||||||
Female | 63 | 72 | 61 | 61 | 74 | 61 | 64 | 64 | 68 | |||
Male | 229 | 220 | 229 | 232 | 220 | 226 | 227 | 228 | 223 | |||
Histology, WHO type | 0.873 | 0.019 | 0.318 | |||||||||
II | 8 | 7 | 9 | 2 | 13 | 9 | 5 | 11 | 8 | |||
III | 284 | 285 | 281 | 291 | 281 | 278 | 286 | 281 | 283 | |||
Clinical stage | 0.242 | <0.001 | <0.001 | |||||||||
III | 196 | 178 | 179 | 225 | 179 | 149 | 235 | 190 | 128 | |||
IVa-b | 96 | 114 | 111 | 68 | 115 | 138 | 56 | 102 | 163 | |||
Tumor stage | <0.001 | 0.009 | <0.001 | |||||||||
T1 | 19 | 6 | 5 | 8 | 8 | 14 | 13 | 6 | 11 | |||
T2 | 55 | 29 | 5 | 20 | 39 | 30 | 20 | 33 | 36 | |||
T3 | 167 | 177 | 189 | 203 | 169 | 161 | 214 | 177 | 142 | |||
T4 | 51 | 80 | 91 | 62 | 78 | 82 | 44 | 76 | 102 | |||
Node stage | 0.192 | <0.001 | <0.001 | |||||||||
N0 | 34 | 41 | 33 | 94 | 11 | 3 | 60 | 33 | 15 | |||
N1 | 84 | 96 | 113 | 124 | 102 | 67 | 134 | 103 | 56 | |||
N2 | 124 | 112 | 107 | 65 | 133 | 145 | 83 | 127 | 133 | |||
N3 | 50 | 43 | 37 | 10 | 48 | 72 | 14 | 29 | 87 | |||
Treatment | 0.512 | <0.001 | <0.001 | |||||||||
RT | 17 | 23 | 16 | 26 | 16 | 14 | 27 | 18 | 11 | |||
CCRT | 103 | 84 | 93 | 125 | 84 | 71 | 133 | 93 | 54 | |||
NACT+CCRT | 164 | 180 | 176 | 133 | 190 | 197 | 130 | 171 | 219 | |||
CCRT+AC | 8 | 5 | 5 | 9 | 4 | 5 | 1 | 10 | 7 | |||
Radiotherapy technique | 0.525 | 0.823 | 0.168 | |||||||||
2DRT/3DCRT | 73 | 70 | 81 | 72 | 75 | 77 | 70 | 68 | 86 | |||
IMRT | 219 | 222 | 209 | 221 | 219 | 210 | 221 | 224 | 205 | |||
VCA-IgA | 0.210 | 0.020 | <0.001 | |||||||||
<1:80 | 84 | 89 | 70 | 99 | 73 | 71 | 108 | 82 | 53 | |||
≥1:80 | 208 | 203 | 220 | 194 | 221 | 216 | 183 | 210 | 238 | |||
EA-IgA | 0.156 | <0.001 | <0.001 | |||||||||
<1:10 | 126 | 129 | 107 | 150 | 102 | 110 | 153 | 119 | 90 | |||
≥1:10 | 166 | 163 | 183 | 143 | 192 | 177 | 138 | 173 | 201 | |||
Smoking | 0.302 | 0.132 | 0.09 | |||||||||
No | 170 | 188 | 180 | 191 | 183 | 164 | 194 | 172 | 172 | |||
Yes | 122 | 104 | 110 | 102 | 111 | 123 | 97 | 120 | 119 | |||
Family history of NPC | 0.855 | 0.876 | 0.102 | |||||||||
No | 258 | 262 | 257 | 261 | 263 | 253 | 266 | 261 | 250 | |||
Yes | 34 | 30 | 33 | 32 | 31 | 34 | 25 | 31 | 41 |
Abbreviations: 2DRT = two-dimensional radiotherapy; 3DCRT = three-dimensional conformal radiotherapy; IMRT = intensity-modulated radiotherapy; VCA = viral capsid antigen; EA = early antigen; NPC = nasopharyngeal carcinoma follow-up; RT = radiation alone; CCRT = concurrent chemoradiotherapy; NACT + CCRT = neoadjuvant chemotherapy + concurrent chemoradiotherapy; CCRT + AC =concurrent chemoradiotherapy + adjuvant chemotherapy