Abstract
A large-scale survey of the normal magnesium content of various human tissues was carried out to facilitate clinical detection of magnesium deficiency, especially occult deficiency.
A review of the literature favours the magnesium content of skeletal muscle as the most reliable index of the body's store of magnesium.
There is a significant difference (P < 0·001) in both the serum and erythrocyte magnesium levels between normal pregnant women in the third trimester and the average normal population. The reason for this difference is discussed.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BARNES B. A., GORDON E. B., COPE O. Skeletal muscle analyses in health and in certain metabolic disorders. I. The method of analysis and the values in normal muscle. J Clin Invest. 1957 Aug;36(8):1239–1248. doi: 10.1172/JCI103521. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COOPER A. R., FORBES R. M., MITCHELL H. H. Further studies on the gross composition and mineral elements of the adult human body. J Biol Chem. 1956 Dec;223(2):969–975. [PubMed] [Google Scholar]
- COTLOVE E., HOLLIDAY M. A., SCHWARTZ R., WALLACE W. M. Effects of electrolyte depletion and acid-base disturbance on muscle cations. Am J Physiol. 1951 Dec;167(3):665–675. doi: 10.1152/ajplegacy.1951.167.3.665. [DOI] [PubMed] [Google Scholar]
- DAWSON J. B., HEATON F. W. The determination of magnesium in biological materials by atomic absorption spectrophotometry. Biochem J. 1961 Jul;80:99–106. doi: 10.1042/bj0800099. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DICKERSON J. W., WIDDOWSON E. M. Chemical changes in skeletal muscle during development. Biochem J. 1960 Feb;74:247–257. doi: 10.1042/bj0740247. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dunn M. J., Walser M. Magnesium depletion in normal man. Metabolism. 1966 Oct;15(10):884–895. doi: 10.1016/0026-0495(66)90159-4. [DOI] [PubMed] [Google Scholar]
- FOURMAN P., MORGAN D. B. Chronic magnesium deficiency. Proc Nutr Soc. 1962;21:34–41. doi: 10.1079/pns19620008. [DOI] [PubMed] [Google Scholar]
- HERRING W. B., LEAVELL B. S., PAIXO L. M., YOE J. H. Trace metals in human plasma and red blood cells. A study of magnesium, chromium, nickel, copper and zinc. I. Obser- vations of normal subjects. Am J Clin Nutr. 1960 Nov-Dec;8:846–854. doi: 10.1093/ajcn/6.2.846. [DOI] [PubMed] [Google Scholar]
- MACINTYRE I., DAVIDSSON D. The production of secondary potassium depletion, sodium retention, nephrocalcinosis and hypercalcaemia by magnesium deficiency. Biochem J. 1958 Nov;70(3):456–462. doi: 10.1042/bj0700456. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MACINTYRE I., HANNA S., BOOTH C. C., READ A. E. Intracellular magnesium deficiency in man. Clin Sci. 1961 Jun;20:297–305. [PubMed] [Google Scholar]
- WACKER W. E., VALLEE B. L. Magnesium metabolism. N Engl J Med. 1958 Sep 4;259(10):475–concl. doi: 10.1056/NEJM195809042591005. [DOI] [PubMed] [Google Scholar]
- WALLACH S., CAHILL L. N., ROGAN F. H., JONES H. L. Plasma and erythrocyte magnesium in health and disease. J Lab Clin Med. 1962 Feb;59:195–210. [PubMed] [Google Scholar]
- WIDDOWSON E. M., DICKERSON J. W. The effect of growth and function on the chemical composition of soft tissues. Biochem J. 1960 Oct;77:30–43. doi: 10.1042/bj0770030. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WILSON A. O. Electrolyte content of muscle samples obtained at surgical operations. Br J Surg. 1955 Jul;43(177):71–75. doi: 10.1002/bjs.18004317710. [DOI] [PubMed] [Google Scholar]
- Watchorn E., McCance R. A. Inorganic constituents of cerebrospinal fluid: The ultrafiltration of calcium and magnesium from human sera. Biochem J. 1932;26(1):54–64. doi: 10.1042/bj0260054. [DOI] [PMC free article] [PubMed] [Google Scholar]