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. 2015 Sep 30;6(34):35755–35769. doi: 10.18632/oncotarget.5928

Figure 6. Synthetic lethal interactions with checkpoint kinases in human tumor samples.

Figure 6

A.-C.CHEK1, CHEK2, and WEE1 are all over expressed in tumors with either homozygous deletion or mutation of RAD17. D. Kaplan-Meier plot of patients from TCGA stratified by overexpression of CHEK1, CHEK2, or WEE1. Red curve - patients with overexpression of none of CHEK1, CHEK2, or WEE1; blue curve - patients with overexpression of one of the three; green curve - overexpression of two of three; purple curve overexpression of all three. E. Proportion of patients alive at five years for same populations, error bars represent +/− 95% CI.