Table 1. Frequency of DPH3 promoter mutations in different cancer types.
| Melanoma n=304 | Basal Cell Carcinoma n=137c | Squamous Cell Carcinoma n=31e | |
|---|---|---|---|
| All mutations | 30 (10%) | 57 (42%) | 12 (39%) |
| −8C>T | 14a (5%) | 27 (20%) | 3 (9%) |
| −9C>T | 12b (4%) | 13 (9%) | 5 (16%) |
| −8/−9CC>TT | 2 (1%) | 14d (10%) | 3f (10%) |
| −9C>A | 1 | 2 | 1 |
| −12C>T | 1 | 1 | 0 |
Mutation names refer to the position from DPH3 TSS (RefSeq) and correspond to the following hg19 coordinates: −8C>T = chr3:16,306,504 C>T mutations, −9C>T/A = chr3:16,306,505 C>T/A mutations, −8/9CC>TT = chr3:16,306,504-16,306,505 CC>TT mutations, −12C>T = chr3:16,306,508 C>T mutations.
One tumor also carried additional −12C>T and another one −37G>A mutation.
One tumor also carried −12C>T mutation.
Out of 137 BCC tumors, for 119 matched samples from surrounding skin tissues were also tested, which did not harbor DPH3 promoter mutations.
One tumor also carried −12C>T and another one −13C>T mutation.
Out of 31 SCC tumors, DNA from 19 matched surrounding skin tissues were also screened, which did not harbor DPH3 promoter mutations.
One tumor additionally carried −12/−13CC>TT tandem mutation.