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. 2015 Sep 15;6(34):36789–36814. doi: 10.18632/oncotarget.5103

Figure 7. Activation of non-canonical NFκB signaling pathway in human and murine BCCs.

Figure 7

A. Activation NFκB in human BCCs as shown by co-immunoprecipitation, EMSA and super-shift assays. B. EMSA/super-shift assays showing the activation of NFκB in UVB- and IR-induced murine BCCs. C. Co-expression of Bcl3 and p50 in mouse BCCs and in BCCs obtained from patients with NBCCS. Co-nuclear localization of Bcl3 and p50 proteins representing yellow nuclear staining (original magnification 40X). D. Western blot analysis showing expression of Bcl3 and Snail in nuclear lysates prepared from BCCs and tumor-adjacent skin; Expression of Bcl3 downstream transcription targets of Cyclin D1 and N-cadherin. E. Western blot showing expression of Snail, Cylindromatous (CYLD), Bcl3, N-cadherin and Cyclin D1 in whole cell lysates prepared from UVB-induced BCCs and tumor adjacent skin. F. Flow diagram showing regulation of Bcl3 and its downstream targets Cyclin D1 and N-cadherin.