Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1969 Sep;22(5):539–544. doi: 10.1136/jcp.22.5.539

Peritoneal infections in patients on long-term peritoneal dialysis before and after human cadaveric renal transplantation

D A Leigh 1,1
PMCID: PMC474243  PMID: 4903622

Abstract

Long-term peritoneal dialysis was carried out on 38 patients awaiting human cadaveric renal transplantation. Fifty-eight per cent of patients developed infection before transplantation and 41% of those requiring dialysis after transplantation became infected.

Infection did not usually occur before the third day of dialysis and 26% of patients developed their first episode of infection in the first week. Almost 50% of patients had only a single episode of infection.

The overall rate of infection per 100 patient days of dialysis was 1·23 before transplantation and 4·17 after transplantation.

The commonest infecting organisms were Staph aureus and Staph albus and these organisms were frequently isolated from the skin around the dialysis catheter before the infection occurred. Gram-negative infections were more commonly seen after transplantation.

Sixty-five per cent of the infections responded to a single course of antibiotic therapy administered in the dialysis fluid. After transplantation Gram-negative infections were usually associated with severe complications and were a major cause of death.

Peritoneal dialysis is a convenient way of maintaining patients with chronic renal failure before human cadaveric renal transplantation, and infection, although common is not inevitable, provided precautions are taken to ensure that the dialysis procedure is carried out using aseptic techniques and prophylactic therapy is applied to the skin around the dialysis catheter.

Full text

PDF
539

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURNS R. O., HENDERSON L. W., HAGER E. B., MERRILL J. P. Peritoneal dialysis. Clinical experience. N Engl J Med. 1962 Nov 22;267:1060–1066. doi: 10.1056/NEJM196211222672103. [DOI] [PubMed] [Google Scholar]
  2. Boen S. T., Mion C. M., Curtis F. K., Shilipetar G. Periodic peritoneal dialysis using the repeated puncture technique and an automatic cycling machine. Trans Am Soc Artif Intern Organs. 1964;10:409–414. [PubMed] [Google Scholar]
  3. Cohen S. L., Percival A. Prolonged peritoneal dialysis in patients awaiting renal transplantation. Br Med J. 1968 Feb 17;1(5589):409–413. doi: 10.1136/bmj.1.5589.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gillies R. R., Govan J. R. Typing of Pseudomonas pyocyanea by pyocine production. J Pathol Bacteriol. 1966 Apr;91(2):339–345. doi: 10.1002/path.1700910207. [DOI] [PubMed] [Google Scholar]
  5. MAXWELL M. H., ROCKNEY R. E., KLEEMAN C. R., TWISS M. R. Peritoneal dialysis. 1. Technique and applications. J Am Med Assoc. 1959 Jun 20;170(8):917–924. doi: 10.1001/jama.1959.03010080025004. [DOI] [PubMed] [Google Scholar]
  6. Montgomerie J. Z., Kalmanson G. M., Guze L. B. Renal failure and infection. Medicine (Baltimore) 1968 Jan;47(1):1–32. doi: 10.1097/00005792-196801000-00001. [DOI] [PubMed] [Google Scholar]
  7. Ribot S., Jacobs M. G., Frankel H. J., Bernstein A. Complications of peritoneal dialysis. Am J Med Sci. 1966 Nov;252(5):505–517. [PubMed] [Google Scholar]
  8. SCHWEINBURG F. B., SELIGMAN A. M., FINE J. Transmural migration of intestinal bacteria; a study based on the use of radioactive Escherichia coli. N Engl J Med. 1950 May 11;242(19):747–751. doi: 10.1056/NEJM195005112421903. [DOI] [PubMed] [Google Scholar]
  9. Schwartz F. D., Kallmeyer J., Dunea G., Kark R. M. Prevention of infection during peritoneal dialysis. JAMA. 1967 Jan 9;199(2):79–81. [PubMed] [Google Scholar]
  10. Stewart J. H., Tuckwell L. A., Sinnett P. F., Edwards K. D., Whyte H. M. Peritoneal and haemodialysis: a comparison of their morbidity, and of the mortality suffered by dialysed patients. Q J Med. 1966 Jul;35(139):407–420. [PubMed] [Google Scholar]
  11. THOMSON W. B., BUCHANAN A. A., DOAK P. B., PEART W. S. PERITONEAL DIALYSIS. Br Med J. 1964 Apr 11;1(5388):932–935. doi: 10.1136/bmj.1.5388.932. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. WILLIAMS J. D., LEIGH D. A., ROSSER E. I., BRUMFITT W., PATH M. C. THE ORGANIZATION AND RESULTS OF A SCREENING PROGRAMME FOR THE DETECTION OF BACTERIURIA OF PREGNANCY. J Obstet Gynaecol Br Commonw. 1965 Jun;72:327–335. doi: 10.1111/j.1471-0528.1965.tb01466.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES