Figure 2.
Cumulative incidence of osteonecrosis in the discovery cohort based on genotype for top BMP7 variants. All 5 patients in the discovery cohort (82 cases, 287 controls) carrying variant alleles of 2 SNPs in high LD (rs77556622 [T>C], rs76599360 [C>T]; P = 1.13 × 10−9) located 3′ to BMP7 developed osteonecrosis. Patient age, ancestry, sex, and therapy group are shown next to each case of osteonecrosis in the variant allele group. Therapy groups are defined in the supplemental Materials, with group 1 receiving the most intense therapy and group 4 receiving the least intense.