Table 1.
Top SNPs from the discovery cohort validated in replication cohort
| RSID | Gene | Risk allele | Discovery MAF cases | Discovery MAF controls | Discovery cohort P* | Discovery cohort HR (95% CI) | Replication cohort P† |
|---|---|---|---|---|---|---|---|
| rs79085477 | BMP7 | T | 0.03 | 0 | 5.34 × 10−8 | 15.0 (5.64-39.7) | .0498 |
| rs75161997 | T | ||||||
| rs1891059 | PROX1-AS1 | A | 0.061 | 0.017 | 2.28 × 10−7 | 6.48 (3.19-13.2) | .008 |
| rs115602884 | T | ||||||
| rs74533616 | T | ||||||
| rs141059755 | LINC00251 | G | 0.018 | 0.002 | 8.48 × 10−7 | 23.3 (6.65-81.5) | .003 |
| rs80223967 | PROX1-AS1 | G | 0.061 | 0.019 | 6.63 × 10−7 | 6.1 (2.99-12.4) | .01 |
| rs17021408 | PROX1-AS1 | C | 0.061 | 0.023 | 1.01 × 10−6 | 5.89 (2.89-12.0) | .01 |
| rs61818937 | A | ||||||
| rs117532069 | DOK5 | A | 0.018 | 0.0017 | 1.71 × 10−6 | 21.0 (6.03-72.9) | .003 |
*
P value for association of SNP genotype with osteonecrosis risk in discovery cohort (N = 369).
†
P value for association of SNP genotype with osteonecrosis in the replication cohort (N = 817).