Abstract
BACKGROUND--7S collagen, an N-terminal peptide of type IV collagen, is a primary constituent of the basement membrane. To evaluate whether the serum concentration of 7S collagen reflects the severity of inflammatory lung disease, the serum concentration of 7S collagen was measured in patients with adult respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis (IPF). METHODS--A radioimmunoassay was used for the measurement of 7S collagen. Gas exchange abnormality was expressed as the arterial oxygen tension (PaO2) divided by the fractional concentration of inspired oxygen (FiO2). RESULTS--The mean (SD) concentration of 7S collagen was 2.7 (0.9) ng/ml in 10 healthy subjects, 5.0 (1.5) ng/ml in 11 patients with IPF, and 14.8 (9.7) ng/ml in 13 patients with ARDS. Significant differences were observed between the patients with ARDS and both healthy subjects and the patients with IPF. In the patients with ARDS serum concentrations of 7S collagen were strongly related to PaO2/FiO2 (r = -0.61). Moreover, the mean (SD) serum concentration of 7S collagen in the eight patients with ARDS who died (19.5 (10.2) ng/ml) was considerably higher than that of the five who survived (7.1 (2.1) ng/ml). CONCLUSION--These results suggest that serum levels of the 7S fragment of type IV collagen may have some prognostic value in ARDS.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bentsen K. D., Horn T., Risteli J., Risteli L., Engström-Laurent A., Hørslev-Petersen K., Lorenzen I. Serum aminoterminal type III procollagen peptide and the 7S domain of type IV collagen in patients with alcohol abuse. Relation to ultrastructural fibrosis in the acinar zone 3 and to serum hyaluronan. Liver. 1987 Dec;7(6):339–346. doi: 10.1111/j.1600-0676.1987.tb00365.x. [DOI] [PubMed] [Google Scholar]
- Bentsen K. D., Horn T., Risteli J., Risteli L., Engström-Laurent A., Hørslev-Petersen K., Lorenzen I. Serum aminoterminal type III procollagen peptide and the 7S domain of type IV collagen in patients with alcohol abuse. Relation to ultrastructural fibrosis in the acinar zone 3 and to serum hyaluronan. Liver. 1987 Dec;7(6):339–346. doi: 10.1111/j.1600-0676.1987.tb00365.x. [DOI] [PubMed] [Google Scholar]
- Dorinsky P. M., Gadek J. E. Multiple organ failure. Clin Chest Med. 1990 Dec;11(4):581–591. [PubMed] [Google Scholar]
- Fowler A. A., Hyers T. M., Fisher B. J., Bechard D. E., Centor R. M., Webster R. O. The adult respiratory distress syndrome. Cell populations and soluble mediators in the air spaces of patients at high risk. Am Rev Respir Dis. 1987 Nov;136(5):1225–1231. doi: 10.1164/ajrccm/136.5.1225. [DOI] [PubMed] [Google Scholar]
- Mainardi C. L., Dixit S. N., Kang A. H. Degradation of type IV (basement membrane) collagen by a proteinase isolated from human polymorphonuclear leukocyte granules. J Biol Chem. 1980 Jun 10;255(11):5435–5441. [PubMed] [Google Scholar]
- Misaki M., Shima T., Yano Y., Sumita Y., Kano U., Murata T., Watanabe S., Suzuki S. Basement membrane-related and type III procollagen-related antigens in serum of patients with chronic viral liver disease. Clin Chem. 1990 Mar;36(3):522–524. [PubMed] [Google Scholar]
- Niemelä O., Risteli L., Sotaniemi E. A., Risteli J. Type IV collagen and laminin-related antigens in human serum in alcoholic liver disease. Eur J Clin Invest. 1985 Jun;15(3):132–137. doi: 10.1111/j.1365-2362.1985.tb00156.x. [DOI] [PubMed] [Google Scholar]
- Risteli J., Bächinger H. P., Engel J., Furthmayr H., Timpl R. 7-S collagen: characterization of an unusual basement membrane structure. Eur J Biochem. 1980;108(1):239–250. doi: 10.1111/j.1432-1033.1980.tb04717.x. [DOI] [PubMed] [Google Scholar]