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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: Virology. 2015 Nov 21;488:73–80. doi: 10.1016/j.virol.2015.10.030

Fig. 5.

Fig. 5

A–F Additional back of the tongue lesions targeted the circumvallate papilla. A) H and E (40x) of a longitudinal parasagittal section of the tongue of animal 4-3L experimentally infected vaginally. At the caudal margin of the dorsal tongue near the reflection to the palatine mucosa and involving the ducts of the lingual salivary (Von Ebner’s) glands and associated circumvallate papilla, there is focally extensive epithelial hyperplasia with dysplasia and viral cytopathic effect (CPE). B) ISH (40x) of an adjacent section showing strong DNA positivity in the same dysplastic area. C) H and E of lesion targeting the circumvallate papilla of animal 10-3(100x). D) ISH of the same lesion showing DNA positivity. E) H and E of lesion targeting the circumvallate papilla of animal 7-2L (100x). F) ISH of the same lesion showing DNA positivity(100x).