Abstract
Serum IgG concentration was lower in Jamaicans than in Nigerians. The maternalfoetal IgG ratio was also lower in Jamaican sera than in Nigerian sera. It is suggested that endemic malaria in Nigeria may be responsible for these differences. The higher IgM concentration in the Nigerian cord sera may be further evidence of this. Eighteen new cases of myeloma were detected in Jamaicans between August 1966 and May 1967. Based on Gm typing, only two of these showed evidence of mixed white ancestry. All the others had the typical Gm groups of Negroes. Similarly, only two patients out of a total of 17 with malignant lymphoma showed evidence of mixed white ancestry. Twelve of the patients with myeloma showed serum proteins of the IgG type, five were IgA, and one had only light chains in the serum. The majority of the patients had myeloma protein of the kappa type. The Gm typing suggested that six patients had myeloma protein of the γ1 heavy chain subclass, and one patient had a γ3 subclass heavy chain, the remainder belonging most likely to the γ2 heavy chain subclass since γ2 occurs about four times as frequently as γ4.
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Selected References
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- CLARK D. W., MACMAHON B. The incidence of multiple myeloma. J Chronic Dis. 1956 Nov;4(5):508–515. [PubMed] [Google Scholar]
- DAVIES P. M. THE ENERGY RELATIONS OF CARASSIUM AURATUS L. I. FOOD INPUT AND ENERGY EXTRACTION EFFICIENCY AT TWO EXPERIMENTAL TEMPERATURES. Comp Biochem Physiol. 1964 May;12:67–79. doi: 10.1016/0010-406x(64)90050-7. [DOI] [PubMed] [Google Scholar]
- EDOZIEN J. C. The serum proteins of healthy adult Nigerians. J Clin Pathol. 1957 Aug;10(3):276–279. doi: 10.1136/jcp.10.3.276. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Grey H. M., Kohler P. F. A case of tetramer Bence Jones proteinaemia. Clin Exp Immunol. 1968 Mar;3(3):277–285. [PMC free article] [PubMed] [Google Scholar]
- KUNKEL H. G., ALLEN J. C., GREY H. M., MARTENSSON L., GRUBB R. A RELATIONSHIP BETWEEN THE H CHAIN GROUPS OF 7S GAMMA-GLOBULIN AND THE GM SYSTEM. Nature. 1964 Jul 25;203:413–414. doi: 10.1038/203413a0. [DOI] [PubMed] [Google Scholar]
- McFarlane H. Multiple myeloma in Jamaica: a study of 40 cases with special reference to the incidence and laboratory diagnosis. J Clin Pathol. 1966 May;19(3):268–271. doi: 10.1136/jcp.19.3.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rowe D. S., McGregor I. A., Smith S. J., Hall P., Williams K. Plasma immunoglobulin concentrations in a West African (Gambian) community and in a group of healthy British adults. Clin Exp Immunol. 1968 Jan;3(1):63–79. [PMC free article] [PubMed] [Google Scholar]
- SCHEIDEGGER J. J. Une micro-méthode de l'immuno-electrophorèse. Int Arch Allergy Appl Immunol. 1955;7(2):103–110. [PubMed] [Google Scholar]
- STEINBERG A. G. Evidence for a Gm allele negative for both Gm(a) and Gm(b). Vox Sang. 1962;7:89–92. doi: 10.1111/j.1423-0410.1962.tb03233.x. [DOI] [PubMed] [Google Scholar]
- Terry W. D., Fahley J. L., Steinberg A. G. GM and INV factors in subclasses of human IgG. J Exp Med. 1965 Dec 1;122(6):1087–1102. doi: 10.1084/jem.122.6.1087. [DOI] [PMC free article] [PubMed] [Google Scholar]