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. 1970 Apr;23(3):193–202. doi: 10.1136/jcp.23.3.193

Histopathological findings in the combined immunity-deficiency syndrome

Colin L Berry 1
PMCID: PMC474524  PMID: 5420732

Abstract

The histopathological appearances of the thymus, lymph nodes, spleen, and gut-associated lymphoid tissue (tonsil, Peyer's patches, and appendix) in cases of the combined immunity-deficiency syndrome are presented. The appearance of tissues remaining after foetal thymic transplants and the effects of such transplants on the morphology of lymph nodes are also discussed.

Although thymic appearances are remarkably constant the picture in the lymph nodes and spleen may vary considerably. The tonsils, Peyer's patches, and appendix appear to constitute one lymphoid organ in man, at least with regard to the developmental arrest that may occur in this syndrome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berry C. L. The neonatal thymus and immune paresis. Proc R Soc Med. 1968 Sep;61(9):867–871. doi: 10.1177/003591576806100907. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Berry C. L., Thompson E. N. Clinico-pathological study of thymic dysplasia. Arch Dis Child. 1968 Oct;43(231):579–584. doi: 10.1136/adc.43.231.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Blackburn W. R., Gordon D. S. The thymic remnant in thymic alymphoplasia. Light and electron microscopic studies. Arch Pathol. 1967 Oct;84(4):363–375. [PubMed] [Google Scholar]
  4. Cooper M. D., Perey D. Y., McKneally M. F., Gabrielsen A. E., Sutherland D. E., Good R. A. A mammalian equivalent of the avian bursa of Fabricius. Lancet. 1966 Jun 25;1(7452):1388–1391. doi: 10.1016/s0140-6736(66)90300-x. [DOI] [PubMed] [Google Scholar]
  5. De Koning J., Van Bekkum D. W., Dicke K. A., Dooren L. J., Rádl J., Van Rood J. J. Transplantation of bone-marrow cells and fetal thymus in an infant with lymphopenic immunological deficiency. Lancet. 1969 Jun 21;1(7608):1223–1227. doi: 10.1016/s0140-6736(69)92112-6. [DOI] [PubMed] [Google Scholar]
  6. Deodhar S. D., Kuklinca A. G., Vidt D. G., Robertson A. L., Hazard J. B. Development of reticulum-cell sarcoma at the site of antilymphocyte globulin injection in a patient with renal transplant. N Engl J Med. 1969 May 15;280(20):1104–1106. doi: 10.1056/NEJM196905152802007. [DOI] [PubMed] [Google Scholar]
  7. Dische M. R. Lymphoid tissue and associated congenital malformations in thymic agenesis. Findings in one infant and two severely malformed stillborns. Arch Pathol. 1968 Sep;86(3):312–316. [PubMed] [Google Scholar]
  8. FARQUHAR J. W., CLAIREAUX A. E. Familial haemophagocytic reticulosis. Arch Dis Child. 1952 Dec;27(136):519–525. doi: 10.1136/adc.27.136.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. GITLIN D., CRAIG J. M. THE THYMUS AND OTHER LYMPHOID TISSUES IN CONGENITAL AGAMMAGLOBULINEMIA. I. THYMIC ALYMPHOPLASIA AND LYMPHOCYTIC HYPOPLASIA AND THEIR RELATION TO INFECTION. Pediatrics. 1963 Oct;32:517–530. [PubMed] [Google Scholar]
  10. GITLIN D., VAWTER G., CRAIG J. M. THYMIC ALYMPHOPLASIA AND CONGENITAL ALEUKOCYTOSIS. Pediatrics. 1964 Feb;33:184–192. [PubMed] [Google Scholar]
  11. GLANZMANN E., RINIKER P. Essentielle Lymphocytophthise; ein neues Krankheitsbild aus der Säuglingspathologie. Ann Paediatr. 1950 Jul-Aug;175(1-2):1–32. [PubMed] [Google Scholar]
  12. Kretschmer R., Jeannet M., Mereu T. R., Kretschmer K., Winn H., Rosen F. S. Hereditary thymic dysplasia: a graft-versus-host reaction induced by bone marrow cells with a partial 4a series histoincompatibility. Pediatr Res. 1969 Jan;3(1):34–40. doi: 10.1203/00006450-196901000-00005. [DOI] [PubMed] [Google Scholar]
  13. Miller M. E., Schieken R. M. Thymic dysplasia. A separable entity from "swiss agammaglobulinemia". Am J Med Sci. 1967 Jun;253(6):741–750. doi: 10.1097/00000441-196706000-00012. [DOI] [PubMed] [Google Scholar]
  14. Perey D. Y., Cooper M. D., Good R. A. Lymphoepithelial tissues of the intestine and differentiation of antibody production. Science. 1968 Jul 19;161(3838):265–266. doi: 10.1126/science.161.3838.265. [DOI] [PubMed] [Google Scholar]
  15. Perey D. Y., Good R. A. Experimental arrest and induction of lymphoid development in intestinal lymphoepithelial tissues of rabbits. Lab Invest. 1968 Jan;18(1):15–26. [PubMed] [Google Scholar]
  16. Standen A. C., Esterly J. R., Pearson B. Reticular cell response to transplants. Reactive changes in the rabbit appendix. Arch Pathol. 1969 Jan;87(1):57–62. [PubMed] [Google Scholar]
  17. TOBLER R., COTTIER H. Familiäre Lymphopenie mit Agammaglobulinämie und schwerer Moniliasis: die essentielle Lymphocytophthise als besondere Form der frühkindlichen Agammaglobulinamie. Helv Paediatr Acta. 1958 Oct;13(4):313–338. [PubMed] [Google Scholar]

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