Abstract
In a case of neuroblastoma the presence of an abnormal blood constituent was suspected from the raised erythrocyte sedimentation rate, sludging of the red cells, marked rouleaux formation, an atypical Leishman stain, increased plasma viscosity, and a distorted protein electrophoresis pattern. The abnormal constituent was shown to be a mucopolysaccharide which was either hyaluronic acid or chondroitin sulphate.
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- ASBOE-HANSEN G., CLAUSEN J. URINARY EXCRETION OF ACID MUCOPOLYSACCHARIDES IN TWELVE CASES OF MASTOCYTOSIS (URTICARIA PIGMENTOSA). J Invest Dermatol. 1964 Jul;42:81–85. [PubMed] [Google Scholar]
- CARSON N. A., NEILL D. W. Metabolic abnormalities detected in a survey of mentally backward individuals in Northern Ireland. Arch Dis Child. 1962 Oct;37:505–513. doi: 10.1136/adc.37.195.505. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DAVIDSON E., HOFFMAN P., LINKER A., MEYER K. The acid mucopolysaccharides of connective tissue. Biochim Biophys Acta. 1956 Sep;21(3):506–518. doi: 10.1016/0006-3002(56)90188-3. [DOI] [PubMed] [Google Scholar]
- DECKER B., McGUCKIN W. F., McKENZIE B. F., SLOCUMB C. H. Concentration of hyaluronic acid in synovial fluid. Clin Chem. 1959 Oct;5:465–469. [PubMed] [Google Scholar]
- DEUTSCH H. F. Some properties of a human serum hyaluronic acid. J Biol Chem. 1957 Feb;224(2):767–774. [PubMed] [Google Scholar]
- HARINGTON J. S., WAGNER J. C., SMITH M. The detection of hyaluronic acid in pleural fluids of cases with diffuse pleural mesotheliomas. Br J Exp Pathol. 1963 Feb;44:81–83. [PMC free article] [PubMed] [Google Scholar]
- JENSEN C. E. Hyaluronic acid. IV. Isolation of hyaluronic acid from pseudomucinous ovarian cysts. Acta Pharmacol Toxicol (Copenh) 1954;10(1):83–88. doi: 10.1111/j.1600-0773.1954.tb01324.x. [DOI] [PubMed] [Google Scholar]
- Manley G., Severn M., Hawksworth J. Excretion patterns of glycosaminoglycans and glycoproteins in normal human urine. J Clin Pathol. 1968 May;21(3):339–345. doi: 10.1136/jcp.21.3.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morse B. S., Nussbaum M. The detection of hyaluronic acid in the serum and urine of a patient with nephroblastoma. Am J Med. 1967 Jun;42(6):996–1002. doi: 10.1016/0002-9343(67)90080-0. [DOI] [PubMed] [Google Scholar]


