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. 2015 Oct 19;6(39):41809–41824. doi: 10.18632/oncotarget.6166

Figure 5. Dietary feeding of FKA inhibits prostate tumorigenesis and blocks metastasis in the TRAMP model.

Figure 5

A. Schematic presentation of prevention and intervention protocols by FKA in the TRAMP model. B. Left panel: Representative H&E staining of prostates in 12-weeks-old, vehicle control versus 0.3% FKA diet fed TRAMP mice. 100 × magnifications of images are shown. Right panel: Percentages of HG-PIN or adenocarcinoma lesions in the prostates of 12-week-old, vehicle control versus 0.3% FKA diet fed TRAMP mice. The prostates were from 8 mice in each group, and the total number of prostate acinus was counted 841 for control group, and 857 for FKA treatment group. Fisher extract tests show Ps<0.05. C. Panel a: The genitourinary weights between 24-weeks-old, control (n=25) and 0.6% FKA (n=21) treated TRAMP mice in the intervention protocol are shown; Panel b: The prostate weights of mice from vehicle control (n=22) and 0.6% FKA (n=20) diet fed groups after mice with neuroendocrine carcinomas were excluded; Panel c: Incidences of palpable tumor and visible lung metastasis between 24-weeks-old, vehicle control versus 0.6% FKA diet fed TRAMP mice.