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. 2015 Oct 20;6(38):41237–41257. doi: 10.18632/oncotarget.5652

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Copyright: © 2015 De Robertis et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. Schematic experimental procedure for groups treated with AOM-alone and/or DSS. Control group (untreated littermate controls) not represented. B. Macroscopic observation of the distal regions of colons from control, AOM-, DSS- and AOM/DSS-treated mice at the end of the 20^th week (only 3 of 6 animals per group are shown). Evident macroscopic lesions detectable only in AOM/DSS-treated colons. C. Hematoxylin/eosin staining of tumors and normal colons. Colon mucosae of AOM-only and DSS-only treated mice show the same histological characteristics of the control group. Adenocarcinomas with a high degree of dysplasia are detectable in AOM/DSS-treated mice. 20x original magnification. Scale bar, 50 μm.