Correction for Sohl et al., Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

BIOCHEMISTRY Correction for “Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ,” by Christal D. Sohl, Michal R. Szymanski, Andrea C. Mislak, Christie K. Shumate, Sheida Amiralaei, Raymond F. Schinazi, Karen S. Anderson, and Y. Whitney Yin, which appeared in issue 28, July 14, 2015, of Proc Natl Acad Sci USA (112:8596–8601; first published June 29, 2015; 10.1073/pnas.1421733112).

The authors note that Fig. 5 appeared incorrectly. The corrected figure and its legend appear below.

Fig. 5.

Functional and structural differences in RT and Pol γ residues surrounding (-)-FTC-TP reveal that the RT incoming nucleotide binding site (A) is more flexible thus less selective than that of human Pol γ (B), which consists of more residues to enhance nucleotide selectivity.