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. 1994 Jun;49(6):594–595. doi: 10.1136/thx.49.6.594

Ultrasound guided pericardial drainage and intrapericardial instillation of mitomycin C for malignant pericardial effusion.

L N Lee 1, P C Yang 1, D B Chang 1, C J Yu 1, J C Ko 1, Y S Liaw 1, R G Wu 1, K T Luh 1
PMCID: PMC474956  PMID: 8016797

Abstract

BACKGROUND--Conservative treatment of malignant pericardial effusion by intrapericardial instillation of a sclerosing agent may be an alternative to surgery. METHODS--Twenty patients with malignant pericardial effusion were treated by ultrasound guided pericardiocentesis and the intrapericardial instillation of mitomycin C. RESULTS--Mitomycin C was effective in controlling the pericardial effusion in 70% of patients without causing side effects, except for pericardial constriction seven months later in one subject. CONCLUSIONS--Ultrasound guided intrapericardial instillation of mitomycin C is a suitable alternative in the management of malignant pericardial effusion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Davis S., Rambotti P., Grignani F. Intrapericardial tetracycline sclerosis in the treatment of malignant pericardial effusion: an analysis of thirty-three cases. J Clin Oncol. 1984 Jun;2(6):631–636. doi: 10.1200/JCO.1984.2.6.631. [DOI] [PubMed] [Google Scholar]
  2. Fiorentino M. V., Daniele O., Morandi P., Aversa S. M., Ghiotto C., Paccagnella A., Fornasiero A. Intrapericardial instillation of platin in malignant pericardial effusion. Cancer. 1988 Nov 1;62(9):1904–1906. doi: 10.1002/1097-0142(19881101)62:9<1904::aid-cncr2820620906>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  3. Imamura T., Tamura K., Takenaga M., Nagatomo Y., Ishikawa T., Nakagawa S. Intrapericardial OK-432 instillation for the management of malignant pericardial effusion. Cancer. 1991 Jul 15;68(2):259–263. doi: 10.1002/1097-0142(19910715)68:2<259::aid-cncr2820680207>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  4. Luh K. T., Yang P. C., Kuo S. H., Chang D. B., Yu C. J., Lee L. N. Comparison of OK-432 and mitomycin C pleurodesis for malignant pleural effusion caused by lung cancer. A randomized trial. Cancer. 1992 Feb 1;69(3):674–679. doi: 10.1002/1097-0142(19920201)69:3<674::aid-cncr2820690313>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  5. Maher E. R., Buckman R. Intrapericardial installation of bleomycin in malignant pericardial effusion. Am Heart J. 1986 Mar;111(3):613–614. doi: 10.1016/0002-8703(86)90080-3. [DOI] [PubMed] [Google Scholar]
  6. Patel A. K., Kosolcharoen P. K., Nallasivan M., Kroncke G. M., Thomsen J. H. Catheter drainage of the pericardium. Practical method to maintain long-term patency. Chest. 1987 Dec;92(6):1018–1021. doi: 10.1378/chest.92.6.1018. [DOI] [PubMed] [Google Scholar]
  7. Smith F. E., Lane M., Hudgins P. T. Conservative management of malignant pericardial effusion. Cancer. 1974 Jan;33(1):47–57. doi: 10.1002/1097-0142(197401)33:1<47::aid-cncr2820330110>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  8. THURBER D. L., EDWARDS J. E., ACHOR R. W. Secondary malignant tumors of the pericardium. Circulation. 1962 Aug;26:228–241. doi: 10.1161/01.cir.26.2.228. [DOI] [PubMed] [Google Scholar]
  9. Theologides A. Neoplastic cardiac tamponade. Semin Oncol. 1978 Jun;5(2):181–192. [PubMed] [Google Scholar]

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