Skip to main content
Thorax logoLink to Thorax
. 1995 Nov;50(11):1219–1220. doi: 10.1136/thx.50.11.1219

Treatment of adenoviral pneumonitis with intravenous ribavirin and immunoglobulin.

I Sabroe 1, J McHale 1, D R Tait 1, W A Lynn 1, K N Ward 1, S Shaunak 1
PMCID: PMC475098  PMID: 8553282

Abstract

A 67 year old woman developed a severe adenoviral pneumonitis whilst receiving immunosuppressive therapy. She showed clinical and radiological evidence of a response to treatment with nebulised and intravenous ribavirin and intravenous pooled normal human immunoglobulin. To our knowledge this is the first time that such a therapeutic approach has been used in the treatment of a condition which normally carries a very high mortality.

Full text

PDF
1219

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buchdahl R. M., Taylor P., Warner J. D. Nebulised ribavirin for adenovirus pneumonia. Lancet. 1985 Nov 9;2(8463):1070–1071. doi: 10.1016/s0140-6736(85)90941-9. [DOI] [PubMed] [Google Scholar]
  2. Cassano W. F. Intravenous ribavirin therapy for adenovirus cystitis after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1991 Mar;7(3):247–248. [PubMed] [Google Scholar]
  3. Dagan R., Schwartz R. H., Insel R. A., Menegus M. A. Severe diffuse adenovirus 7a pneumonia in a child with combined immunodeficiency: possible therapeutic effect of human immune serum globulin containing specific neutralizing antibody. Pediatr Infect Dis. 1984 May-Jun;3(3):246–251. doi: 10.1097/00006454-198405000-00015. [DOI] [PubMed] [Google Scholar]
  4. Dudding B. A., Wagner S. C., Zeller J. A., Gmelich J. T., French G. R., Top F. H., Jr Fatal pneumonia associated with adenovirus type 7 in three military trainees. N Engl J Med. 1972 Jun 15;286(24):1289–1292. doi: 10.1056/NEJM197206152862403. [DOI] [PubMed] [Google Scholar]
  5. Greenberg S. B. Viral pneumonia. Infect Dis Clin North Am. 1991 Sep;5(3):603–621. [PubMed] [Google Scholar]
  6. Hierholzer J. C. Adenoviruses in the immunocompromised host. Clin Microbiol Rev. 1992 Jul;5(3):262–274. doi: 10.1128/cmr.5.3.262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Sidwell R. W., Huffman J. H., Khare G. P., Allen L. B., Witkowski J. T., Robins R. K. Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. Science. 1972 Aug 25;177(4050):705–706. doi: 10.1126/science.177.4050.705. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES