Table 2.

Association between SBP Levels and Incident Stroke Risk among Subjects Aged 60 or Older without Diabetes Mellitus or Chronic Kidney Disease

Sample	SBP, mmHg	N	No. cases	Crude rate	Model 1^*		Model 2^†		Model 3 ^‡

					HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	P_Het^§
All	<140	761	55	6.2	Ref.		Ref.		Ref.
	140-149	354	50	12.3	1.83 (1.24-2.68)	0.002	1.79 (1.20-2.65)	0.004	1.72 (1.15-2.57)	0.008
	≥150	635	77	10.8	1.56 (1.10-2.21)	0.013	1.53 (1.06-2.22)	0.024	1.41 (0.95-2.10)	0.092
	Total	1750	182	9.1
Hispanic	<140	353	17	3.9	Ref.		Ref.		Ref.
	140-149	159	20	10.3	2.57 (1.34-4.90)	0.004	2.49 (1.29-4.80)	0.006	2.61 (1.35-5.07)	0.005	0.039
	≥150	325	43	11.3	2.57 (1.46-4.52)	0.001	2.59 (1.43-4.67)	0.002	2.85 (1.52-5.34)	0.001	0.004
	Total	439	56	11.6
NH-black	<140	166	16	8.7	Ref.		Ref.		Ref.
	140-149	97	18	17.3	1.93 (0.98-3.80)	0.056	2.22 (1.07-4.57)	0.032	1.93 (0.93-4.03)	0.078	0.148
	≥150	176	22	11.3	1.21 (0.63-2.32)	0.560	1.40 (0.70-2.82)	0.339	1.01 (0.47-2.15)	0.983	0.328
	Total	439	56	11.6
NH-white	<140	218	20	8.3	Ref.		Ref.		Ref.
	140-149	89	10	10.1	1.01 (0.47-2.16)	0.987	0.88 (0.39-2.00)	0.760	0.85 (0.37-1.95)	0.700
	≥150	123	9	7.3	0.81 (0.37-1.78)	0.593	0.62 (0.27-1.43)	0.261	0.56 (0.23-1.38)	0.208
	Total	430	39	8.4
Women	<140	465	34	6.1	Ref.		Ref.		Ref.
	140-149				2.12 (1.32-3.41)	0.002	2.04 (1.25-3.31)	0.004	1.98 (1.22-3.24)	0.006	0.369
	≥150	424	51	10.3	1.49 (0.96-2.30)	0.077	1.40 (0.88-2.22)	0.162	1.31 (0.80-2.15)	0.291	0.552
	Total	1105	120	9.2
Men	<140	296	21	6.3	Ref.		Ref.		Ref.
	140-149	138	15	9.7	1.44 (0.74-2.79)	0.284	1.44 (0.71-2.89)	0.310	1.33 (0.65-2.72)	0.442
	≥150 Total	211 645	26 62	11.8 8.8	1.75 (0.98-3.13)	0.057	1.93 (1.04-3.60)	0.038	1.69 (0.86-3.33)	0.131
Age<80	<140	621	37	4.7	Ref.		Ref.		Ref.
	140-149	289	36	10.3	1.97 (1.24-3.12)	0.004	1.94 (1.21-3.14)	0.006	1.90 (1.17-3.08)	0.009	0.507
	≥150	514	62	10.0	1.81 (1.20-2.73)	0.005	1.83 (1.18-2.86)	0.008	1.74 (1.08-2.78)	0.022	0.102
	Total	1424	135	7.7
Age ≥80	<140	140	18	16.8	Ref.		Ref.		Ref.
	140-149	65	14	24.3	1.50 (0.74-3.03)	0.260	1.52 (0.73-3.19)	0.267	1.40 (0.65-3.00)	0.392
	≥150	121	15	16.3	0.99 (0.50-1.97)	0.974	0.92 (0.44-1.94)	0.835	0.80 (0.36-1.79)	0.591
	Total	326	47	18.3

Model 1: adjusted for age, and applicable, for sex and race-ethnicity

^†

Model 2: model 1 additionally adjusted for BP medication use, waist circumference, smoking, moderate alcohol drinking, physical activity, and history of myocardial infarct, atrial fibrillation or coronary artery disease.

^‡

Model 3: model 2 additionally adjusted for DBP.

^§

P_Het: p value for heterogeneity for effect comparison between Hispanic and white, between black and white, between men and women, between age<80 and age≥80.