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Temperature and DHFR mass effects on the pre-steady-state rate constants (kburst; A) and deuterium KIEs (Dkhyd; B) measured by stopped-flow experiments at pH 7 (blue: l-DHFR; red: h-DHFR). The pre-steady-state Dkhyd values (B) are within the experimental errors of intrinsic KIEs measured by competitive experiments at pH 7 (data from ref 38). The kburst and Dkhyd values are also listed in Table S2.
