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. Author manuscript; available in PMC: 2017 Jan 28.
Published in final edited form as: Cell. 2016 Jan 21;164(3):538–549. doi: 10.1016/j.cell.2015.12.050

Figure 4. Replicative asymmetry is concordant across three distinct R-class mutational processes.

Figure 4

Color representing mutational asymmetry is overlaid on replication timing profiles as in Fig. 2. Profiles are shown in triplets colored by: (1) C→A:G→T asymmetry in 12 mutant-POLE colorectal and endometrial genomes; (2) G→C:C→G asymmetry in 22 APOBEC-enriched bladder, breast, and head-and-neck genomes; and (3) A→G:T→C asymmetry in 9 MSI-associated colon genomes.