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. 2015 Nov 26;4:F1000 Faculty Rev-1356. [Version 1] doi: 10.12688/f1000research.7153.1

Figure 1. Detection of varicella zoster virus (VZV) antigen in the temporal artery of a patient with giant cell arteritis.

Figure 1.

Hematoxylin-and-eosin staining of the temporal artery from a 90-year-old man with classic giant cell arteritis ( A). Note extensive inflammation in the adventitia, media and intima, disruption of the media, a thickened intima, and nearly occluded arterial lumen; inset denotes a giant cell. Immunohistochemical staining with mouse anti-VZV gE antibody revealed VZV antigen (red) in the adventitia and media of the temporal artery ( B) that was not seen when mouse isotype IgG1 antibody was substituted for mouse anti-VZV gE antibody ( C).