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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1974 Aug;27(8):652–655. doi: 10.1136/jcp.27.8.652

Serum ferritin in children with thalassaemia regularly transfused

E A Letsky 1,2, F Miller 1,2, M Worwood 1,2, D M Flynn 1,2
PMCID: PMC475423  PMID: 4421996

Abstract

A controlled trial of continuous chelation therapy in regularly transfused children with homozygous β-thalassaemia has been in progress at the Hospital for Sick Children since April 1966. In the sixth and seventh years of the trial the effect of this treatment on iron overload has been assessed by estimating serum ferritin levels and liver iron concentrations in both chelator-treated and control groups. When compared with non-chelated controls, results of both these estimations were invariably lower in the chelated group. However, all the results in both groups were very high, and fell within the ranges observed in untreated idiopathic haemochromatosis. A close correlation was found between serum ferritin levels and liver iron concentrations in these children, indicating that serum ferritin is a valuable alternative to liver iron concentration in the assessment of visceral iron overload, even when massive tissue siderosis is present.

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Selected References

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  1. Addison G. M., Beamish M. R., Hales C. N., Hodgkins M., Jacobs A., Llewellin P. An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. J Clin Pathol. 1972 Apr;25(4):326–329. doi: 10.1136/jcp.25.4.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barry M., Flynn D. M., Letsky E. A., Risdon R. A. Long-term chelation therapy in thalassaemia major: effect on liver iron concentration, liver histology, and clinical progress. Br Med J. 1974 Apr 6;2(5909):16–20. doi: 10.1136/bmj.2.5909.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Barry M. Liver iron concentration, stainable iron, and total body storage iron. Gut. 1974 May;15(5):411–415. doi: 10.1136/gut.15.5.411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HASKINS D., STEVENS A. R., Jr, FINCH S., FINCH C. A. Iron metabolism; iron stores in man as measured by phlebotomy. J Clin Invest. 1952 Jun;31(6):543–547. doi: 10.1172/JCI102639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HOWELL J., WYATT J. P. Development of pigmentary cirrhosis in Cooley's anemia. AMA Arch Pathol. 1953 May;55(5):423–431. [PubMed] [Google Scholar]
  6. Jacobs A., Miller F., Worwood M., Beamish M. R., Wardrop C. A. Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. Br Med J. 1972 Oct 28;4(5834):206–208. doi: 10.1136/bmj.4.5834.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Prieto J., Barry M., Sherlock S. Proceedings: Serum ferritin in patients with iron overload and with acute and chronic liver disease. Gut. 1974 Apr;15(4):343–343. [PubMed] [Google Scholar]
  8. WITZLEBEN C. L., WYATT J. P. The effect of long survival on the pathology of thalassaemia major. J Pathol Bacteriol. 1961 Jul;82:1–12. [PubMed] [Google Scholar]
  9. Walters G. O., Miller F. M., Worwood M. Serum ferritin concentration and iron stores in normal subjects. J Clin Pathol. 1973 Oct;26(10):770–772. doi: 10.1136/jcp.26.10.770. [DOI] [PMC free article] [PubMed] [Google Scholar]

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