Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1974 Aug;27(8):656–663. doi: 10.1136/jcp.27.8.656

Amyloid in normal and pathological parathyroid glands

T J Anderson 1,1, S W B Ewen 1
PMCID: PMC475424  PMID: 4138679

Abstract

Two groups of parathyroid glands have been examined for intrafollicular amyloid. In glands removed surgically it was found in nine cases (16%); in glands removed at necropsy it was found in 23 cases (46%). Also, two postmortem cases of systemic amyloidosis showed involvement of parathyroid glands with an entirely different distribution of amyloid. Compared with other amyloids the tinctorial properties of the intrafollicular amyloid were uniform in reactions with Congo red and Thioflavin T, but the intensity of the staining reaction for amino acids tryptophan and tyrosine was not constant for the follicle amyloid. This variation may be a feature of a maturation process but the derivation of this amyloid remains uncertain.

Full text

PDF
656

Images in this article

657Image
on p.657
657Image
on p.657
659Image
on p.659
660Image
on p.660
661Image
on p.661

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS C. W. A p-dimethylaminobenzaldehyde-nitrite method for the histochemical demonstration of tryptophane and related compounds. J Clin Pathol. 1957 Feb;10(1):56–62. doi: 10.1136/jcp.10.1.56. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anderson T. J. Mast cells in parathyroid glands of hyperparathyroidism. J Clin Pathol. 1974 Jan;27(1):31–34. doi: 10.1136/jcp.27.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Black H. E., Capen C. C., Arnaud C. D. Ultrastructure of parathyroid glands and plasma immunoreactive parathyroid hormone in pregnant cows fed normal and high calcium diets. Lab Invest. 1973 Aug;29(2):173–185. [PubMed] [Google Scholar]
  4. GLENNER G. G., LILLIE R. D. Observations on the diazotization-coupling reaction for the histochemical demonstration of tyrosine: metal chelation and formazan variants. J Histochem Cytochem. 1959 Nov;7:416–422. doi: 10.1177/7.6.416. [DOI] [PubMed] [Google Scholar]
  5. Galante L., Gudmundsson T. V., Matthews E. W., Tse A., Williams E. D., Woodhouse N. J., MacIntyre I. Thymic and parathyroid origin of calcitonin in man. Lancet. 1968 Sep 7;2(7567):537–538. doi: 10.1016/s0140-6736(68)92408-2. [DOI] [PubMed] [Google Scholar]
  6. Glenner G. G., Eanes E. D., Page D. L. The relation of the properties of Congo red-stained amyloid fibrils to the -conformation. J Histochem Cytochem. 1972 Oct;20(10):821–826. doi: 10.1177/20.10.821. [DOI] [PubMed] [Google Scholar]
  7. Glenner G. G., Ein D., Terry W. D. The immunoglobulin origin of amyloid. Am J Med. 1972 Feb;52(2):141–147. doi: 10.1016/0002-9343(72)90063-0. [DOI] [PubMed] [Google Scholar]
  8. Leedham P. W., Pollock D. J. Intrafollicular amyloid in primary hyperparathyroidism. J Clin Pathol. 1970 Dec;23(9):811–817. doi: 10.1136/jcp.23.9.811. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lendrum A. C., Slidders W., Fraser D. S. Renal hyalin. A study of amyloidosis and diabetic fibrinous vasculosis with new staining methods. J Clin Pathol. 1972 May;25(5):373–396. doi: 10.1136/jcp.25.5.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lieberman A., DeLellis R. A. Intrafollicular amyloid in normal parathyroid glands. Arch Pathol. 1973 Jun;95(6):422–423. [PubMed] [Google Scholar]
  11. Martin T. J., Greenberg P. B., Michelangeli V. Synthesis of human parathyroid hormone by cultured cells: evidence for release of prohormone by some adenomata. Clin Sci. 1973 Jan;44(1):1–8. doi: 10.1042/cs0440001. [DOI] [PubMed] [Google Scholar]
  12. PORTA E. A., YERRY R., SCOTT R. F. Amyloidosis of functioning islet cell adenomas of the pancreas. Am J Pathol. 1962 Nov;41:623–631. [PMC free article] [PubMed] [Google Scholar]
  13. Pearse A. G., Ewen S. W., Polak J. M. The genesis of apudamyloid in endocrine polypeptide tumours: histochemical distinction from immunamyloid. Virchows Arch B Cell Pathol. 1972;10(2):93–107. doi: 10.1007/BF02899719. [DOI] [PubMed] [Google Scholar]
  14. Pearse A. G. The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J Histochem Cytochem. 1969 May;17(5):303–313. doi: 10.1177/17.5.303. [DOI] [PubMed] [Google Scholar]
  15. Perkin A. B., Bader H. I., Tashjian A. H., Jr, Goldhaber P. Immunofluorescent localization of parathyroid hormone in extracellular spaces of the bovine parathyroid gland. Proc Soc Exp Biol Med. 1968 May;128(1):218–221. doi: 10.3181/00379727-128-32982. [DOI] [PubMed] [Google Scholar]
  16. Ravid M., Gafni J., Sohar E., Missmahl H. P. Incidence and origin of non-systemic microdeposits of amyloid. J Clin Pathol. 1967 Jan;20(1):15–20. doi: 10.1136/jcp.20.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Rother P. Das Kolloid der Glandulae parathyreoideae. Acta Histochem. 1970;35(1):135–152. [PubMed] [Google Scholar]
  18. SCHWARTZ P. SENILE CEREBRAL, PANCREATIC INSULAR AND CARDIAC AMYLOIDOSIS. Trans N Y Acad Sci. 1965 Feb;27:393–413. doi: 10.1111/j.2164-0947.1965.tb02977.x. [DOI] [PubMed] [Google Scholar]
  19. VASSAR P. S., CULLING C. F. Fluorescent stains, with special reference to amyloid and connective tissues. Arch Pathol. 1959 Nov;68:487–498. [PubMed] [Google Scholar]
  20. Williams E. D., Brown C. L., Doniach I. Pathological and clinical findings in a series of 67 cases of medullary carcinoma of the thyroid. J Clin Pathol. 1966 Mar;19(2):103–113. doi: 10.1136/jcp.19.2.103. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES