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. 1974 Sep;27(9):710–721. doi: 10.1136/jcp.27.9.710

Necropsy studies on adult coeliac disease

H Thompson 1
PMCID: PMC475446  PMID: 4426981

Abstract

The distribution of mucosal changes in adult coeliac disease have been studied in 24 cases within four hours of death. There were six patients on a normal diet who showed flat mucosa in the jejunum, convolutions in the middle third, and digitate villi in the terminal ileum. A more extensive distribution of flat mucosa and convolutions involving most of the small intestine was noted in one case. Eighteen patients had been treated with a gluten-free diet and 11 had responded well clinically and histologically. No evidence of flat mucosa was discovery at necropsy in six of these.

Attention is drawn to the high incidence of malignancy in this series (13 out of 24 cases). Other complications of adult coeliac disease are discussed briefly.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALDERSBERG D., GABRIEL J. B., HIMES H. W. Previously undescribed clinical and postmortem observations in non-tropical sprue; possible role of prolonged corticosteroid therapy. Gastroenterology. 1957 Jan;32(1):60–71. [PubMed] [Google Scholar]
  2. Bayless T. M., Kapelowitz R. F., Shelley W. M., Ballinger W. F., 2nd, Hendrix T. R. Intestinal ulceration--a complication of celiac disease. N Engl J Med. 1967 May 4;276(18):996–1002. doi: 10.1056/NEJM196705042761802. [DOI] [PubMed] [Google Scholar]
  3. Brunt P. W., Sircus W., Maclean N. Neoplasia and the coeliac syndrome in adults. Lancet. 1969 Jan 25;1(7587):180–184. doi: 10.1016/s0140-6736(69)91192-1. [DOI] [PubMed] [Google Scholar]
  4. COOKE J. P. COMMUNICATION AND SOUND TRANSMISSION IN HELIUM AND VARIOUS GASES AT REDUCED PRESSURES. Aerosp Med. 1964 Nov;35:1050–1053. [PubMed] [Google Scholar]
  5. COOKE W. T., BROOKE B. N. Non-specific enterocolitis. Q J Med. 1955 Jan;24(93):1–22. [PubMed] [Google Scholar]
  6. COOKE W. T., FONE D. J., COX E. V., MEYNELL M. J., GADDIE R. ADULT COELIAC DISEASE. Gut. 1963 Sep;4:279–291. doi: 10.1136/gut.4.3.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. CREAMER B. MALIGNANCY AND THE SMALL-INTESTINAL MUCOSA. Br Med J. 1964 Dec 5;2(5422):1435–1436. doi: 10.1136/bmj.2.5422.1435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cooke W. T., Smith W. T. Neurological disorders associated with adult coeliac disease. Brain. 1966 Dec;89(4):683–722. doi: 10.1093/brain/89.4.683. [DOI] [PubMed] [Google Scholar]
  9. Cooke W. T., Thompson H., Williams J. A. Malignancy and adult coeliac disease. Gut. 1969 Feb;10(2):108–111. doi: 10.1136/gut.10.2.108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Dymock I. W., Gray B. Staining method for the examination of the small intestinal villous pattern in necropsy material. J Clin Pathol. 1968 Nov;21(6):748–749. doi: 10.1136/jcp.21.6.748. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ferguson A., Hutton M. M., Maxwell J. D., Murray D. Adult coeliac disease in hyposplenic patients. Lancet. 1970 Jan 24;1(7639):163–164. doi: 10.1016/s0140-6736(70)90405-8. [DOI] [PubMed] [Google Scholar]
  12. GOULSTON K. J., SKYRING A. P., MCGOVERN V. J. ULCERATIVE JEJUNITIS ASSOCIATED WITH MALABSORPTION. Australas Ann Med. 1965 Feb;14:57–64. doi: 10.1111/imj.1965.14.1.57. [DOI] [PubMed] [Google Scholar]
  13. HOURIHANE D. O. DIARRHOEA OF SMALL BOWEL ORIGIN. THE HISTOLOGY OF INTESTINAL BIOPSIES. Proc R Soc Med. 1963 Dec;56:1073–1077. [PMC free article] [PubMed] [Google Scholar]
  14. Harris O. D., Cooke W. T., Thompson H., Waterhouse J. A. Malignancy in adult coeliac disease and idiopathic steatorrhoea. Am J Med. 1967 Jun;42(6):899–912. doi: 10.1016/0002-9343(67)90071-x. [DOI] [PubMed] [Google Scholar]
  15. MACDONALD W. C., BRANDBORG L. L., FLICK A. L., TRIER J. S., RUBIN C. E. STUDIES OF CELIAC SPRUE. IV. THE RESPONSE OF THE WHOLE LENGTH OF THE SMALL BOWEL TO A GLUTEN-FREE DIET. Gastroenterology. 1964 Dec;47:573–589. [PubMed] [Google Scholar]
  16. MARTIN J. B., BELL H. E. THE ASSOCIATION OF SPLENIC ATROPHY AND INTESTINAL MALABSORPTION: REPORT OF A CASE AND REVIEW OF THE LITERATURE. Can Med Assoc J. 1965 Apr 17;92:875–878. [PMC free article] [PubMed] [Google Scholar]
  17. Marks J., Shuster S. Intestinal malabsorption and the skin. Gut. 1971 Nov;12(11):938–947. doi: 10.1136/gut.12.11.938. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Marks J., Shuster S., Watson A. J. Small-bowel changes in dermatitis herpetiformis. Lancet. 1966 Dec 10;2(7476):1280–1282. doi: 10.1016/s0140-6736(66)91692-8. [DOI] [PubMed] [Google Scholar]
  19. Marsh G. W., Stewart J. S. Splenic function in adult coeliac disease. Br J Haematol. 1970 Oct;19(4):445–457. doi: 10.1111/j.1365-2141.1970.tb06972.x. [DOI] [PubMed] [Google Scholar]
  20. McCarthy C. F., Fraser I. D., Evans K. T., Read A. E. Lymphoreticular dysfunction in idiopathic steatorrhoea. Gut. 1966 Apr;7(2):140–148. doi: 10.1136/gut.7.2.140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. PAULLEY J. W. Observation on the aetiology of idiopathic steatorrhoea; jejunal and lymph-node biopsies. Br Med J. 1954 Dec 4;2(4900):1318–1321. doi: 10.1136/bmj.2.4900.1318. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Pettit J. E., Hoffbrand A. V., Seah P. P., Fry L. Splenic atrophy in dermatitis herpetiformis. Br Med J. 1972 May 20;2(5811):438–440. doi: 10.1136/bmj.2.5811.438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. ROYER M., CROXATTO O., BIEMPICA L., BALCAZAR MORRISON A. J. Biopsia duodenal por aspiración bajo control radioscópico. Prensa Med Argent. 1955 Aug 19;42(33):2515–2519. [PubMed] [Google Scholar]
  24. Roy-Choudhury D., Cooke W. T., Tan D. T., Banwell J. G., Smits B. J. Jejunal biopsy: criteria and significance. Scand J Gastroenterol. 1966;1(1):57–74. doi: 10.1080/00365521.1966.11800614. [DOI] [PubMed] [Google Scholar]
  25. SHINER M. Duodenal biopsy. Lancet. 1956 Jan 7;270(6906):17–19. doi: 10.1016/s0140-6736(56)91854-2. [DOI] [PubMed] [Google Scholar]
  26. Shuster S., Watson A. J., Marks J. Coeliac syndrome in dermatitis herpetiformis. Lancet. 1968 May 25;1(7552):1101–1106. doi: 10.1016/s0140-6736(68)90181-5. [DOI] [PubMed] [Google Scholar]

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