Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1974 Oct;27(10):808–812. doi: 10.1136/jcp.27.10.808

Systemic nodular panniculitis with cardiac involvement

P J Wilkinson 1,2, R R M Harman 1,2, C R Tribe 1,2
PMCID: PMC475488  PMID: 4426975

Abstract

A case of systemic nodular panniculitis is described in which the myocardium was found at necropsy to be extensively involved with focal interstitial carditis, identical histologically with nodules of panniculitis biopsied from the skin. This degree of myocardial involvement, which was not apparent during life and was not confined to pericardial or myocardial adipose tissue, has not previously been reported. The literature relating to nodular panniculitis is briefly reviewed and the concept of Weber-Christian disease critically re-appraised.

Full text

PDF
808

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ackerman A. B., Mosher D. T., Schwamm H. A. Factitial Weber-Christian syndrome. JAMA. 1966 Nov 14;198(7):731–736. [PubMed] [Google Scholar]
  2. BEERMAN H. Weber-Christian syndrome. Am J Med Sci. 1953 Apr;225(4):446–462. [PubMed] [Google Scholar]
  3. BRUDNO J. C. Chronic relapsing febrile nodular nonsuppurative panniculitis (Weber-Christian disease); relation to rheumatic fever and allied diseases. N Engl J Med. 1950 Oct 5;243(14):513–517. doi: 10.1056/NEJM195010052431401. [DOI] [PubMed] [Google Scholar]
  4. CRANE J. T., AGUILAR M. J., GRIMES O. F. Isolated lipodystrophy, a form of mesenteric tumor. Am J Surg. 1955 Aug;90(2):169–179. doi: 10.1016/0002-9610(55)90748-0. [DOI] [PubMed] [Google Scholar]
  5. Cantwell A. R., Jr, Craggs E., Swatek F., Wilson J. W. Unusual acid-fast bacteria in panniculitis. Arch Dermatol. 1966 Aug;94(2):161–167. [PubMed] [Google Scholar]
  6. Emmerson R. W. Liquefying nodular panniculitis and diabetes. Proc R Soc Med. 1966 Mar;59(3):252–253. doi: 10.1177/003591576605900324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Epstein E. H., Jr, Oren M. E. Popsicle panniculitis. N Engl J Med. 1970 Apr 23;282(17):966–967. doi: 10.1056/NEJM197004232821709. [DOI] [PubMed] [Google Scholar]
  8. GREENBERG A. I., SATTLER M. E. Bowel obstruction, unusual manifestation of Weber-Christian disease. Wis Med J. 1956 Nov;55(11):1219–1222. [PubMed] [Google Scholar]
  9. GROSSMAN L. A., KAPLAN H. J., PREUSS H. J., HERRINGTON J. L., Jr Mesenteric panniculitis. JAMA. 1963 Feb 2;183:318–323. doi: 10.1001/jama.1963.03700050050011. [DOI] [PubMed] [Google Scholar]
  10. HALLAHAN J. D., KLEIN T. Relapsing febrile nodular nonsuppurative panniculitis (Weber-Christian disease); review of literature and report of case. Ann Intern Med. 1951 May;34(5):1179–1201. doi: 10.7326/0003-4819-34-5-1179. [DOI] [PubMed] [Google Scholar]
  11. HUTT M. S., PINNIGER J. L. Adrenal failure due to bilateral suprarenal infarction associated with systemic nodular panniculitis and endarteritis. J Clin Pathol. 1956 Nov;9(4):316–322. doi: 10.1136/jcp.9.4.316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MILNER R. D., MITCHINSON M. J. SYSTEMIC WEBER-CHRISTIAN DISEASE. J Clin Pathol. 1965 Mar;18:150–156. doi: 10.1136/jcp.18.2.150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Macdonald A., Feiwel M. A review of the concept of Weber-Christian panniculitis with a report of five cases. Br J Dermatol. 1968 Jun;80(6):355–361. doi: 10.1111/j.1365-2133.1968.tb12320.x. [DOI] [PubMed] [Google Scholar]
  14. Macdonald A. Inflammatory diseases of the subcutaneous fat. Geriatrics. 1970 Nov;25(11):156–passim. [PubMed] [Google Scholar]
  15. Macoul K. L. Panniculitis, vasculitis, and a positive lupus erythematosus cell test. JAMA. 1967 Feb 6;199(6):428–430. [PubMed] [Google Scholar]
  16. Ostergaard P. A. Toxoplasmosis as a possible aetiological factor in panniculitis of the weber-christian type. Dan Med Bull. 1970 May;17(5):158–160. [PubMed] [Google Scholar]
  17. PERRY H. O., WINKELMANN R. K. SUBACUTE NODULAR MIGRATORY PANNICULITIS. Arch Dermatol. 1964 Feb;89:170–179. doi: 10.1001/archderm.1964.01590260008002. [DOI] [PubMed] [Google Scholar]
  18. Pinals R. S. Nodular panniculitis associated with an inflammatory bone lesion. Arch Dermatol. 1970 Mar;101(3):359–363. [PubMed] [Google Scholar]
  19. RINALDI V. G. Steatonecrosi cistiche multiple e simultanee da penicillina ritardo. Riforma Med. 1958 Feb 22;72(8):207–209. [PubMed] [Google Scholar]
  20. Robertson J. C., Eeles G. H. Syndrome associated with pancreatic acinar cell carcinoma. Br Med J. 1970 Jun 20;2(5711):708–709. doi: 10.1136/bmj.2.5711.708. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Rosenstock H. A. Weber-Christian disease. Report of a case documenting the presence of leukoagglutinins. JAMA. 1968 Mar 4;203(10):890–891. doi: 10.1001/jama.203.10.890. [DOI] [PubMed] [Google Scholar]
  22. SANFORD H. N., EUBANK D. F., STENN F. Chronic panniculitis with leucopenia (Weber-Christian syndrome). AMA Am J Dis Child. 1952 Feb;83(2):156–163. doi: 10.1001/archpedi.1952.02040060022003. [DOI] [PubMed] [Google Scholar]
  23. STEINBERG B. Systemic nodular panniculitis. Am J Pathol. 1953 Nov-Dec;29(6):1059–1081. [PMC free article] [PubMed] [Google Scholar]
  24. Sarkany I., Macmillan A. L. Recurrent non-scarring pressure panniculitis. Proc R Soc Med. 1969 Dec 12;62(12):1279–1280. doi: 10.1177/003591576906201235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Soergel K. H., Hensley G. T. Fatal mesenteric panniculitis. Gastroenterology. 1966 Oct;51(4):529–536. [PubMed] [Google Scholar]
  26. TEDESCHI C. G., BOTTA G. C. Retractile mesenteritis. N Engl J Med. 1962 May 17;266:1035–1040. doi: 10.1056/NEJM196205172662005. [DOI] [PubMed] [Google Scholar]
  27. Tuffanelli D. L. Lupus erythematosus panniculitis (profundus). Arch Dermatol. 1971 Mar;103(3):231–242. [PubMed] [Google Scholar]
  28. Wyatt E. H. Panniculitis and pancytopenia. Br J Clin Pract. 1969 Nov;23(11):473–476. [PubMed] [Google Scholar]
  29. de Graciansky P. Weber-Christian syndrome of pancreatic origin. Br J Dermatol. 1967 May;79(5):278–283. doi: 10.1111/j.1365-2133.1967.tb11491.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES