Figure 8. Amisulpride modulates midbrain-hippocampal connectivity.
(A) Anatomical seed region in the midbrain is overlaid on a T2-weigthed image averaged across subjects. (B) Functional connectivity between the midbrain and the hippocampus during generalization test is significantly reduced in the amisulpride group (P < 0.05, FWE small volume corrected). For illustration, t-map from two-sample t-test (PP > PA) is thresholded at P < 0.001, uncorrected and overlaid on a T1-weigthed image averaged across subjects. (C) For illustration, bar plot depicting average midbrain-hippocampus connectivity in both groups. (D) Strength of midbrain-hippocampal connectivity is positively correlated with the width of the model-estimated inhibitory generalization coefficient (r = 0.47, P = 0.01) in the amisulpride group. Error bars are SEM for N = 25 (PA) and N = 21 (PP).