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. 2016 Feb 13;3(1):ENEURO.0085-15.2016. doi: 10.1523/ENEURO.0085-15.2016

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Copyright © 2016 Gulledge and Bravo

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 9. — Impact of AIS plasticity on the excitability of morphologically realistic neurons. A, Plots of the mean changes in rheobase currents (percentage ±SD) observed after elongating or shortening the AIS by 5, 10, or 15 µm (relative to a 30-µm-long baseline AIS), across all possible AIS locations within 100 µm of the soma, in reconstructed neuron morphologies having simulated dendritic spines (see Materials and Methods) and uniform sodium and potassium conductance densities in the AIS (AIS Model D). B, Plots of the mean absolute values of changes in rheobase (percentage ±SD) observed after translocating the AIS by 5, 10, or 15 µm across all possible AIS positions within 100 µm of the soma. Note the different y-axis scales in A and B.