Abstract
Of 207 homosexual or bisexual patients with the acquired immune deficiency syndrome (AIDS), 24 with the AIDS related complex, and 39 with asymptomatic HIV infection, 32 patients were found to have mycobacterial infection. Mycobacterium tuberculosis was found in 13 patients with AIDS and in two with the AIDS related complex. M avium-intracellulare was found in 15 patients with AIDS and was disseminated in 12. One patient was infected with M kansasii and one with M ulcerans. Invasive procedures were frequently required to obtain positive bacteriological results. Subclinical carriage of M avium-intracellulare and other mycobacteria thought to be nonpathogenic was common in patients seronegative for the human immunodeficiency virus and at all stages of human immunodeficiency virus infection. All but one isolate of M tuberculosis were fully sensitive to standard antimycobacterial antibiotics. Response to treatment was usually rapid. M avium-intracellulare isolates were all resistant to first line agents in vitro, and antibiotics such as ansamycin and amikacin were required to obtain a clinical response.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anand R., Moore J. L., Curran J. W., Srinivasan A. Interaction between rifabutin and human immunodeficiency virus type 1: inhibition of replication, cytopathic effect, and reverse transcriptase in vitro. Antimicrob Agents Chemother. 1988 May;32(5):684–688. doi: 10.1128/aac.32.5.684. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Armstrong D., Gold J. W., Dryjanski J., Whimbey E., Polsky B., Hawkins C., Brown A. E., Bernard E., Kiehn T. E. Treatment of infections in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1985 Nov;103(5):738–743. doi: 10.7326/0003-4819-103-5-738. [DOI] [PubMed] [Google Scholar]
- Chaisson R. E., Schecter G. F., Theuer C. P., Rutherford G. W., Echenberg D. F., Hopewell P. C. Tuberculosis in patients with the acquired immunodeficiency syndrome. Clinical features, response to therapy, and survival. Am Rev Respir Dis. 1987 Sep;136(3):570–574. doi: 10.1164/ajrccm/136.3.570. [DOI] [PubMed] [Google Scholar]
- Damsker B., Bottone E. J. Mycobacterium avium-Mycobacterium intracellulare from the intestinal tracts of patients with the acquired immunodeficiency syndrome: concepts regarding acquisition and pathogenesis. J Infect Dis. 1985 Jan;151(1):179–181. doi: 10.1093/infdis/151.1.179. [DOI] [PubMed] [Google Scholar]
- Goedert J. J., Weiss S. H., Biggar R. J., Landesman S. H., Weber J., Grossman R. J., Guroff M. R. Lesser AIDS and tuberculosis. Lancet. 1985 Jul 6;2(8445):52–52. doi: 10.1016/s0140-6736(85)90112-6. [DOI] [PubMed] [Google Scholar]
- Graham D. Y., Markesich D. C., Yoshimura H. H. Mycobacteria and inflammatory bowel disease. Results of culture. Gastroenterology. 1987 Feb;92(2):436–442. doi: 10.1016/0016-5085(87)90139-9. [DOI] [PubMed] [Google Scholar]
- Horsburgh C. R., Jr, Cohn D. L., Roberts R. B., Masur H., Miller R. A., Tsang A. Y., Iseman M. D. Mycobacterium avium-M. intracellulare isolates from patients with or without acquired immunodeficiency syndrome. Antimicrob Agents Chemother. 1986 Dec;30(6):955–957. doi: 10.1128/aac.30.6.955. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Iseman M. D. Is standard chemotherapy adequate in tuberculosis patients infected with the HIV? Am Rev Respir Dis. 1987 Dec;136(6):1326–1326. doi: 10.1164/ajrccm/136.6.1325. [DOI] [PubMed] [Google Scholar]
- Iseman M. D. Is standard chemotherapy adequate in tuberculosis patients infected with the HIV? Am Rev Respir Dis. 1987 Dec;136(6):1326–1326. doi: 10.1164/ajrccm/136.6.1325. [DOI] [PubMed] [Google Scholar]
- Macher A. M., Kovacs J. A., Gill V., Roberts G. D., Ames J., Park C. H., Straus S., Lane H. C., Parrillo J. E., Fauci A. S. Bacteremia due to Mycobacterium avium-intracellulare in the acquired immunodeficiency syndrome. Ann Intern Med. 1983 Dec;99(6):782–785. doi: 10.7326/0003-4819-99-6-782. [DOI] [PubMed] [Google Scholar]
- Meeran K. Prevalence of HIV infection among patients with leprosy and tuberculosis in rural Zambia. BMJ. 1989 Feb 11;298(6670):364–365. doi: 10.1136/bmj.298.6670.364. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Millar A. B. Respiratory manifestations of AIDS. Br J Hosp Med. 1988 Mar;39(3):204–215. [PubMed] [Google Scholar]
- Mycobacterioses and the acquired immunodeficiency syndrome. Joint Position Paper of the American Thoracic Society and the Centers for Disease Control. Am Rev Respir Dis. 1987 Aug;136(2):492–496. doi: 10.1164/ajrccm/136.2.492. [DOI] [PubMed] [Google Scholar]
- Pinching A. J., McManus T. J., Jeffries D. J., Moshtael O., Donaghy M., Parkin J. M., Munday P. E., Harris J. R. Studies of cellular immunity in male homosexuals in London. Lancet. 1983 Jul 16;2(8342):126–130. doi: 10.1016/s0140-6736(83)90115-0. [DOI] [PubMed] [Google Scholar]
- Reichman L. B., Felton C. P., Edsall J. R. Drug dependence, a possible new risk factor for tuberculosis disease. Arch Intern Med. 1979 Mar;139(3):337–339. [PubMed] [Google Scholar]
- Smith P. D., Macher A. M., Bookman M. A., Boccia R. V., Steis R. G., Gill V., Manischewitz J., Gelmann E. P. Salmonella typhimurium enteritis and bacteremia in the acquired immunodeficiency syndrome. Ann Intern Med. 1985 Feb;102(2):207–209. doi: 10.7326/0003-4819-102-2-207. [DOI] [PubMed] [Google Scholar]
- Sunderam G., McDonald R. J., Maniatis T., Oleske J., Kapila R., Reichman L. B. Tuberculosis as a manifestation of the acquired immunodeficiency syndrome (AIDS). JAMA. 1986 Jul 18;256(3):362–366. [PubMed] [Google Scholar]
- Wong B., Edwards F. F., Kiehn T. E., Whimbey E., Donnelly H., Bernard E. M., Gold J. W., Armstrong D. Continuous high-grade mycobacterium avium-intracellulare bacteremia in patients with the acquired immune deficiency syndrome. Am J Med. 1985 Jan;78(1):35–40. doi: 10.1016/0002-9343(85)90458-9. [DOI] [PubMed] [Google Scholar]