Abstract
The anticoagulant activity of heparin dissolved in intravenous solutions was measured by two different methods of heparin assay. Both procedures showed markedly reduced anticoagulant activity within four hours after the addition of heparin to the solutions. When measured according to the procedure of Yin, heparin in the intravenous solutions fully regained its lost anticoagulant activity after 24 hours at room temperature. When measured by the thrombin time, however, the heparin anticoagulant activity reamained reduced. The source of heparin, from either the lung or intestine, does not explain the reduction in anticoagulant activity. Although its cause is unknown, the erratic behaviour of heparin in intravenous solutions stresses the importance of a laboratory monitor of heparin therapy.
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Selected References
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- BAUER G. CLINICAL EXPERIENCES OF A SURGEON IN THE USE OF HEPARIN. Am J Cardiol. 1964 Jul;14:29–35. doi: 10.1016/0002-9149(64)90101-8. [DOI] [PubMed] [Google Scholar]
- Chessells J. M., Braithwaite T. A., Chamberlain D. A. Dextrose and sorbitol as diluents for continuous intravenous heparin infusion. Br Med J. 1972 Apr 8;2(5805):81–82. doi: 10.1136/bmj.2.5805.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Congdon J. E., Kardinal C. G., Wallin J. D. Monitoring heparin therapy in hemodialysis. A report on the activated whole blood coagulation time tests. JAMA. 1973 Dec 24;226(13):1529–1533. doi: 10.1001/jama.226.13.1529. [DOI] [PubMed] [Google Scholar]
- Genton E. Guidelines for heparin therapy. Ann Intern Med. 1974 Jan;80(1):77–82. doi: 10.7326/0003-4819-80-1-77. [DOI] [PubMed] [Google Scholar]
- Jacobs J., Kletter D., Superstine E., Hill K. R., Lynn B., Webb R. A. Intravenous infusions of heparin and penicillins. J Clin Pathol. 1973 Oct;26(10):742–746. doi: 10.1136/jcp.26.10.742. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pitney W. R., Pettit J. E., Armstrong L. Control of heparin therapy. Br Med J. 1970 Oct 17;4(5728):139–141. doi: 10.1136/bmj.4.5728.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stock S. L., Warner N. Heparin in acid solutions. Br Med J. 1971 Jul 31;3(5769):307–307. doi: 10.1136/bmj.3.5769.307-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yin E. T., Wessler S., Butler J. V. Plasma heparin: a unique, practical, submicrogram-sensitive assay. J Lab Clin Med. 1973 Feb;81(2):298–310. [PubMed] [Google Scholar]