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. 1975 Jul;28(7):543–546. doi: 10.1136/jcp.28.7.543

A study of immunoglobulin M antibody to measles, canine distemper, and rinderpest viruses in sera of patients with subacute sclerosing panencephalitis.

D Thomson, J H Connolly, B O Underwood, F Brown
PMCID: PMC475767  PMID: 1097472

Abstract

Seven boys were studied who had the clinical features of subacute sclerosing panencephalitis (SSPE) and whose brain histology was consistent with SSPE. Measles antigen was detected in the seven brains by the direct fluorescent antibody method. Three out of the seven boys had in their sera measles specific immunoglobulin M (IgM) which was detected by the indirect fluorescent antibody method, and the cell receptors for it were acetone stable. A prozone effect was noted in the sera of two patients. The absorption of one patient's serum with Staphylococcus aureus to reduce the titre of immunoglobulin G (IgG) removed the prozone effect. Two of the boys who had high titres of measles specific IgM also had serum IgM which reacted with canine distemper virus antigen but the titres were eightfold lower. None of the boys had detectable rinderpest specific IgM in their sera.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Banatvala J. E., Best J. M., Waller D. K. Epstein-Barr virus-specific IgM in infectious mononucleosis, Burkitt lymphoma, nasopharyngeal carcinoma. Lancet. 1972 Jun 3;1(7762):1205–1208. doi: 10.1016/s0140-6736(72)90925-7. [DOI] [PubMed] [Google Scholar]
  2. Cohen I. R., Norins L. C., Julian A. J. Competition between, and effectiveness of, IgG and IgM antibodies in indirect fluorescent antibody and other tests. J Immunol. 1967 Jan;98(1):143–149. [PubMed] [Google Scholar]
  3. Connolly J. H., Allen I. V., Hurwitz L. J., Millar J. H. Measles-virus antibody and antigen in subacute sclerosing panencephalitis. Lancet. 1967 Mar 11;1(7489):542–544. doi: 10.1016/s0140-6736(67)92117-4. [DOI] [PubMed] [Google Scholar]
  4. Connolly J. H., Allen I. V., Hurwitz L. J., Millar J. H. Subacute sclerosing panencephalitis. Clinical, pathological, epidemiological, and virological findings in three patients. Q J Med. 1968 Oct;37(148):625–644. [PubMed] [Google Scholar]
  5. Connolly J. H., Haire M., Hadden D. S. Measles immunoglobulins in subacute sclerosing panencephalitis. Br Med J. 1971 Jan 2;1(5739):23–25. doi: 10.1136/bmj.1.5739.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cradock-Watson J. E., Bourne M. S., Vandervelde E. M. IgG, IgA and IgM responses in acute rubella determined by the immunofluorescent technique. J Hyg (Lond) 1972 Sep;70(3):473–485. doi: 10.1017/s0022172400063063. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fraser K. B., Haire M., Shirodaria P. V., Millar J. H. Letter: Multiple sclerosis and virus antigens. Lancet. 1973 Dec 1;2(7840):1271–1271. doi: 10.1016/s0140-6736(73)91018-0. [DOI] [PubMed] [Google Scholar]
  8. Imagawa D. T. Relationships among measles, canine distemper and rinderpest viruses. Prog Med Virol. 1968;10:160–193. [PubMed] [Google Scholar]
  9. Juchau S. V., Linscott W. D., Schachter J., Jawetz E. Inhibition of antichlamydial IgM antibody by IgG antibody in immunofluorescence tests. J Immunol. 1972 Jun;108(6):1563–1569. [PubMed] [Google Scholar]
  10. Kurtz J. B. Specific IgG and IgM antibody responses in herpes-simplex-virus infections. J Med Microbiol. 1974 Aug;7(3):333–341. doi: 10.1099/00222615-7-3-333. [DOI] [PubMed] [Google Scholar]
  11. Najera R., Gracia Saiz A., Herrera I., Valenciano L. Serological and tissue culture observations from cases of subacute sclerosing panencephalitis. Ann Inst Pasteur (Paris) 1972 Oct;123(4):565–570. [PubMed] [Google Scholar]
  12. Schmitz H., Haas R. Determination of different cytomegalovirus immunoglobulins (IgG, IgA, IgM) by immunofluorescence. Arch Gesamte Virusforsch. 1972;37(1):131–140. doi: 10.1007/BF01241158. [DOI] [PubMed] [Google Scholar]
  13. Shirodaria P. V., Fraser K. B., Stanford F. Secondary fluorescent staining of virus antigens by rheumatoid factor and fluorescein-conjugated anti-IgM. Ann Rheum Dis. 1973 Jan;32(1):53–57. doi: 10.1136/ard.32.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Skaug K., Tjotta E. Diagnosis of recent Herpes simplex infections. A modified immunofluorescent test for the detection of specific Herpes simplex IgM antibodies after staphylococcal adsorption of IgG. Acta Pathol Microbiol Scand B Microbiol Immunol. 1974 Jun;82(3):323–328. [PubMed] [Google Scholar]

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