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. 1975 Aug;28(8):659–663. doi: 10.1136/jcp.28.8.659

Muscle fibre type changes in hypothyroid myopathy.

R O McKeran, G Slavin, T M Andrews, P Ward, W G Mair
PMCID: PMC475797  PMID: 1184764

Abstract

Changes in muscle fibre type in hypothyroid myopathy were studied by serial percutaneous needle biopsy of vastus lateralis before and during treatment with L-thyroxine. A type II fibre atrophy and loss was found, which correlated with the clinical and biochemical evidence of a myopathy. The type II fibre atrophy was corrected by L-thyroxine but type II fibre loss was still apparent in severely myopathic patients up to two years after starting treatment. The pathogenesis and significance of type II fibre atrophy and loss are discussed in relation to prognosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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