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. Author manuscript; available in PMC: 2016 Jul 30.
Published in final edited form as: Cell. 2015 Jul 16;162(3):493–504. doi: 10.1016/j.cell.2015.06.057

Figure 4. In Vivo Activity of Ab513 in AG129 and Humanized Mice.

Figure 4

(A) AG129 mice (n = 10) were treated with Ab513, an irrelevant IgG1 mAb (“Isotype control”), or PBS prior to challenge with 106.4 CCID50 of DENV-2. Viremia from serum 3 days post-infection (dpi) was measured by qRT-PCR. Dotted line represents limit of detection. The three dots on the x axis represent values (samples) below the lower limit of detection.

(B) A separate cohort of animals were monitored for survival. ***p < 0.0001, as compared with PBS controls.

(C–F) Comparison of human platelet levels in uninfected and infected humanized mice (humice) without treatment or treated with an isotype control Ab (“Control Ab”) or Ab513. The dashed line indicates the average of human platelet counts in uninfected humice. Results are shown as the average counts of human platelets per microliter of blood at different days post-infection (n = 5–7). **p < 0.05. Log-rank (Mantel-Cox) statistical test was performed to assess for significance. Error bars denote SD.