Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1975 Oct;28(10):775–778. doi: 10.1136/jcp.28.10.775

A comparison of the in vitro activity of metronidazole, tinidazole, and nimorazole against Gram-negative anaerobic bacilli.

A V Reynolds, J M Hamilton-Miller, W Brumfitt
PMCID: PMC475858  PMID: 1214009

Abstract

The in vitro activities of metronidazole, nimorazole, and tinidazole were compared against 69 strains of obligately anaerobic Gram-negative bacilli. Geometric mean MICs were 0-34, 1-05, and 0-28 mug/ml respectively. Thirty-six strains were also tested by the disk method. Correlation between MIC and diameter of the zones of inhibition was poor.

Full text

PDF
775

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DAVIES A. H., MCFADZEAN J. A., SQUIRES S. TREATMENT OF VINCENT'S STOMATITIS WITH METRONIDAZOLE. Br Med J. 1964 May 2;1(5391):1149–1150. doi: 10.1136/bmj.1.5391.1149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. De Carneri I. Antiprotozoan activity of nitroimidazoles. Arzneimittelforschung. 1969 Mar;19(3):382–386. [PubMed] [Google Scholar]
  3. Dornbusch K., Nord C. E. In vitro effect of metronidazole and tinidazole on anaerobic bacteria. Med Microbiol Immunol. 1974;160(4):265–267. doi: 10.1007/BF02121441. [DOI] [PubMed] [Google Scholar]
  4. Edwards D. I., Dye M., Carne H. The selective toxicity of antimicrobial nitroheterocyclic drugs. J Gen Microbiol. 1973 May;76(1):135–145. doi: 10.1099/00221287-76-1-135. [DOI] [PubMed] [Google Scholar]
  5. Ericsson H. M., Sherris J. C. Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;217(Suppl):1+–1+. [PubMed] [Google Scholar]
  6. Finegold S. M., Harada N. E., Miller L. G. Antibiotic susceptibility patterns as aids in classification and characterization of gram-negative anaerobic bacilli. J Bacteriol. 1967 Nov;94(5):1443–1450. doi: 10.1128/jb.94.5.1443-1450.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Füzi M., Csukás Z. A metronidazol egy eddig ismeretlen antibacterialis hatása. Orv Hetil. 1969 Jul 13;110(28):1605–1606. [PubMed] [Google Scholar]
  8. Füzi M., Csukás Z. Das antibakterielle Wirkungsspektrum des Metronidazols. Zentralbl Bakteriol Orig. 1970;213(2):258–262. [PubMed] [Google Scholar]
  9. Füzi M., Csukás Z. Veillonella-törzsek metronidazol-érzékenysége. Fogorv Sz. 1969 Nov;62(11):324–326. [PubMed] [Google Scholar]
  10. Howes H. L., Jr, Lynch J. E., Kivlin J. L. Tinidazole, a new antiprotozoal agent: Effect on Trichomonas and other protozoa. Antimicrob Agents Chemother (Bethesda) 1969;9:261–266. [PubMed] [Google Scholar]
  11. Lozdan J., Sheiham A., Pearlman B. A., Keiser B., Rachanis C. C., Meyer R. The use of nitrimidazine in the treatment of acute ulcerative gingivitis. A double-blind controlled trial. Br Dent J. 1971 Apr 6;130(7):294–296. doi: 10.1038/sj.bdj.4802660. [DOI] [PubMed] [Google Scholar]
  12. Mitchell A. A. Incidence and isolation of Bacteroides species from clinical material and their sensitivity to antibiotics. J Clin Pathol. 1973 Oct;26(10):738–741. doi: 10.1136/jcp.26.10.738. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nastro L. J., Finegold S. M. Bactericidal activity of five antimicrobial agents against Bacteroides fragilis. J Infect Dis. 1972 Jul;126(1):104–107. doi: 10.1093/infdis/126.1.104. [DOI] [PubMed] [Google Scholar]
  14. Prince H. N., Grunberg E., Titsworth E., DeLorenzo W. F. Effects of l-(2-nitro-l-imidazolyl)-3-methoxy-2-propanol and 2-methyl-5-nitroimidazole-l-ethanol against anaerobic and aerobic bacteria and protozoa. Appl Microbiol. 1969 Nov;18(5):728–730. doi: 10.1128/am.18.5.728-730.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Reynolds A. V., Hamilton-Miller J. M., Brumfitt W. Newer aminoglycosides--amikacin and tobramycin: an in-vitro comparison with kanamycin and gentamicin. Br Med J. 1974 Sep 28;3(5934):778–780. doi: 10.1136/bmj.3.5934.778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. SHINN D. L., SQUIRES S., MCFADZEAN J. A. THE TREATMENT OF VINCENT'S DISEASE WITH METRONIDAZOLE. Dent Pract Dent Rec. 1965 Apr;15:275–280. [PubMed] [Google Scholar]
  17. Staneck J. L., Washington J. A., 2nd Antimicrobial susceptibilities of anaerobic bacteria: recent clinical isolates. Antimicrob Agents Chemother. 1974 Sep;6(3):311–315. doi: 10.1128/aac.6.3.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Tally F. P., Armfield A. Y., Dowell V. R., Jr, Kwok Y. Y., Sutter V. L., Finegold S. M. Susceptibility of Clostridium ramosum to antimicrobial agents. Antimicrob Agents Chemother. 1974 Jun;5(6):589–593. doi: 10.1128/aac.5.6.589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tally F. P., Sutter V. L., Finegold S. M. Metronidazole versus anaerobes. In vitro data and initial clinical observations. Calif Med. 1972 Dec;117(6):22–26. [PMC free article] [PubMed] [Google Scholar]
  20. Videau D. Association métronidazole-spiramycin sur les germes anaérobies. Pathol Biol (Paris) 1971 Jun-Jul;19(11):661–666. [PubMed] [Google Scholar]
  21. Welling P. G., Monro A. M. The pharmacokinetics of metronidazole and tinidazole in man. Arzneimittelforschung. 1972 Dec;22(12):2128–2132. [PubMed] [Google Scholar]
  22. Whelan J. P., Hale J. H. Bactericidal activity of metronidazole against Bacteroides fragilis. J Clin Pathol. 1973 Jun;26(6):393–395. doi: 10.1136/jcp.26.6.393. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES