Abstract
A case is described of Weber-Christian panniculitis accompanied by a gammaglobulin disturbance which preceded by five years the diagnosis of an autoimmune hepatitis and pancytopenia. Also associated was the onset of diabetes mellitus, found at necropsy to be related to pancreatic islet amyloid deposition. This case reinforces the view that Weber-Christian panniculitis may be an adipose response to a variety of immunological stimuli.
Full text
PDF





Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ackerman A. B., Mosher D. T., Schwamm H. A. Factitial Weber-Christian syndrome. JAMA. 1966 Nov 14;198(7):731–736. [PubMed] [Google Scholar]
- BEERMAN H. Weber-Christian syndrome. Am J Med Sci. 1953 Apr;225(4):446–462. [PubMed] [Google Scholar]
- BELL E. T. Hyalinization of the islet of Langerhans in diabetes mellitus. Diabetes. 1952 Sep-Oct;1(5):341–344. doi: 10.2337/diab.1.5.341. [DOI] [PubMed] [Google Scholar]
- EHRLICH J. C., RATNER I. M. Amyloidosis of the islets of Langerhans. A restudy of islet hyalin in diabetic and non-diabetic individuals. Am J Pathol. 1961 Jan;38:49–59. [PMC free article] [PubMed] [Google Scholar]
- Goddard J. W. Granuloma, a Characteristic "Qualitative" Change in Focal Anaphylactic Inflammation. Am J Pathol. 1947 Nov;23(6):943–965. [PMC free article] [PubMed] [Google Scholar]
- Hellstrom H. R., Perezstable E. C. Retroperitoneal fibrosis with disseminated vasculitis and intrahepatic sclerosing cholangitis. Am J Med. 1966 Feb;40(2):184–187. doi: 10.1016/0002-9343(66)90098-2. [DOI] [PubMed] [Google Scholar]
- MILNER R. D., MITCHINSON M. J. SYSTEMIC WEBER-CHRISTIAN DISEASE. J Clin Pathol. 1965 Mar;18:150–156. doi: 10.1136/jcp.18.2.150. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Macdonald A., Feiwel M. A review of the concept of Weber-Christian panniculitis with a report of five cases. Br J Dermatol. 1968 Jun;80(6):355–361. doi: 10.1111/j.1365-2133.1968.tb12320.x. [DOI] [PubMed] [Google Scholar]
- Macdonald A. Inflammatory diseases of the subcutaneous fat. Geriatrics. 1970 Nov;25(11):156–passim. [PubMed] [Google Scholar]
- Maclaren N. K., Huang S. W., Fogh J. Antibody to cultured human insulinoma cells in insulin-dependent diabetes. Lancet. 1975 May 3;1(7914):997–1000. doi: 10.1016/s0140-6736(75)91945-5. [DOI] [PubMed] [Google Scholar]
- Macoul K. L. Panniculitis, vasculitis, and a positive lupus erythematosus cell test. JAMA. 1967 Feb 6;199(6):428–430. [PubMed] [Google Scholar]
- Mitsutani S., Hiraide S., Matsumoto H. [Systemic Weber-Christian disease complicated with pancytopenia and megaloblastosis: report of a case with autopsy (author's transl)]. Rinsho Ketsueki. 1973 Oct;14(10):1054–1059. [PubMed] [Google Scholar]
- Rosenstock H. A. Weber-Christian disease. Report of a case documenting the presence of leukoagglutinins. JAMA. 1968 Mar 4;203(10):890–891. doi: 10.1001/jama.203.10.890. [DOI] [PubMed] [Google Scholar]
- STEINBERG B. Systemic nodular panniculitis. Am J Pathol. 1953 Nov-Dec;29(6):1059–1081. [PMC free article] [PubMed] [Google Scholar]
- Spain D. M., Foley J. M. Nonsuppurative Nodular Panniculitis (Weber-Christian's Disease). Am J Pathol. 1944 Jul;20(4):783–787. [PMC free article] [PubMed] [Google Scholar]
- Tuffanelli D. L. Lupus erythematosus panniculitis (profundus). Arch Dermatol. 1971 Mar;103(3):231–242. [PubMed] [Google Scholar]
- Wyatt E. H. Panniculitis and pancytopenia. Br J Clin Pract. 1969 Nov;23(11):473–476. [PubMed] [Google Scholar]