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. 1976 Mar;29(3):224–227. doi: 10.1136/jcp.29.3.224

Chemotaxis, random mobility, and mobilization of polymorphonuclear leucocytes in malnutrition.

R K Chandra, S Chandra, O P Ghai
PMCID: PMC476027  PMID: 1270603

Abstract

Neutrophil mobilization following administration of Pseudomonas polysaccharide was significantly reduced in malnutrition, especially during infection. The random mobility of polymorphonuclear leucocytes (PMNs) was slightly decreased in undernutrition. Chemotactic migration of PMNs was depressed and correlated more with the presence of infection than with nutritional deficiency. It is possible that these abnormalities of PMN mobilization and mobility in malnourished individuals contribute to suboptimal amount, kinetics, and pattern of tissue inflammatory response to bacteraemic challenge.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Antia A. U., McFarlane H., Soothill J. F. Serum siderophilin in kwashiorkor. Arch Dis Child. 1968 Aug;43(230):459–462. doi: 10.1136/adc.43.230.459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bhuyan U. N., Ramalingaswami V. Responses of the protein-deficient rabbit to staphylococcal bacteremia. Am J Pathol. 1972 Nov;69(2):359–368. [PMC free article] [PubMed] [Google Scholar]
  3. Chandra R. K. Fetal malnutrition and postnatal immunocompetence. Am J Dis Child. 1975 Apr;129(4):450–454. doi: 10.1001/archpedi.1975.02120410038013. [DOI] [PubMed] [Google Scholar]
  4. Chandra R. K. Immunocompetence in undernutrition. J Pediatr. 1972 Dec;81(6):1194–1200. doi: 10.1016/s0022-3476(72)80262-2. [DOI] [PubMed] [Google Scholar]
  5. Chandra R. K. Letter: Immunocompetence in low-birth-weight infants after intrauterine malnutrition. Lancet. 1974 Dec 7;2(7893):1393–1394. doi: 10.1016/s0140-6736(74)92272-7. [DOI] [PubMed] [Google Scholar]
  6. Chandra R. K. Reduced secretory antibody response to live attenuated measles and poliovirus vaccines in malnourished children. Br Med J. 1975 Jun 14;2(5971):583–585. doi: 10.1136/bmj.2.5971.583. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Chandra R. K. Rosette-forming T lymphocytes and cell-mediated immunity in malnutrition. Br Med J. 1974 Sep 7;3(5931):608–609. doi: 10.1136/bmj.3.5931.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Chandra R. K. Serum complement and immunoconglutinin in malnutrition. Arch Dis Child. 1975 Mar;50(3):225–229. doi: 10.1136/adc.50.3.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Feigin R. D., Shackelford P. G., Choi S. C., Flake K. K., Franklin F. A., Jr, Eisenberg C. S. Nitroblue tetrazolium dye test as an aid in the differential diagnosis of febrile disorders. J Pediatr. 1971 Feb;78(2):230–237. doi: 10.1016/s0022-3476(71)80005-7. [DOI] [PubMed] [Google Scholar]
  10. Ferguson A. C., Lawlor G. J., Jr, Neumann C. G., Oh W., Stiehm E. R. Decreased rosette-forming lymphocytes in malnutrition and intrauterine growth retardation. J Pediatr. 1974 Nov;85(5):717–723. doi: 10.1016/s0022-3476(74)80527-5. [DOI] [PubMed] [Google Scholar]
  11. Geefhuysen J., Rosen E. U., Katz J., Ipp T., Metz J. Impaired cellular immunity in kwashiorkor with improvement after therapy. Br Med J. 1971 Nov 27;4(5786):527–529. doi: 10.1136/bmj.4.5786.527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McFarlane H., Hamid J. Cell-mediated immune response in malnutrition. Clin Exp Immunol. 1973 Jan;13(1):153–164. [PMC free article] [PubMed] [Google Scholar]
  13. Miller M. E., Nilsson U. R. A familial deficiency of the phagocytosis-enhancing activity of serum related to a dysfunction of the fifth component of complement (C5). N Engl J Med. 1970 Feb 12;282(7):354–358. doi: 10.1056/NEJM197002122820702. [DOI] [PubMed] [Google Scholar]
  14. Rosen E. U., Geefhuysen J., Anderson R., Joffe M., Rabson A. R. Leucocyte function in children with kwashiorkor. Arch Dis Child. 1975 Mar;50(3):220–224. doi: 10.1136/adc.50.3.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Selvaraj R. J., Bhat K. S. [Metabolic and bactericidal activities of leukocytes in protein-calorie malnutrition]. Am J Clin Nutr. 1972 Feb;25(2):166–174. doi: 10.1093/ajcn/25.2.166. [DOI] [PubMed] [Google Scholar]
  16. Seth V., Chandra R. K. Opsonic activity, phagocytosis, and bactericidal capacity of polymorphs in undernutrition. Arch Dis Child. 1972 Apr;47(252):282–284. doi: 10.1136/adc.47.252.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Sirisinha S., Edelman R., Suskind R., Charupatana C., Olson R. E. Complement and C3-proactivator levels in children with protein-calorie malnutrition and effect of dietary treatment. Lancet. 1973 May 12;1(7811):1016–1020. doi: 10.1016/s0140-6736(73)90663-6. [DOI] [PubMed] [Google Scholar]
  18. Smythe P. M., Brereton-Stiles G. G., Grace H. J., Mafoyane A., Schonland M., Coovadia H. M., Loening W. E., Parent M. A., Vos G. H. Thymolymphatic deficiency and depression of cell-mediated immunity in protein-calorie malnutrition. Lancet. 1971 Oct 30;2(7731):939–943. doi: 10.1016/s0140-6736(71)90267-4. [DOI] [PubMed] [Google Scholar]
  19. Sood S. K., Deo M. G., Ramalingaswami V. Anemia in experimental protein deficiency in the rhesus monkey with special reference to iron metabolism. Blood. 1965 Oct;26(4):421–432. [PubMed] [Google Scholar]

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